St6galnac5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: St6galnac5provided by RGD
Official Full Name: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5provided by RGD
Primary source: RGD:1564252
See related: EnsemblRapid:ENSRNOG00000049676 AllianceGenome:RGD:1564252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Siat7E; ST6GalNAcV
Summary: Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process and oligosaccharide biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Orthologous to human ST6GALNAC5 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905725.1 and NW_007905726.1 in NCBI's Rattus norvegicus Annotation Release 105. [18 Jun 2015]
Expression: Biased expression in Brain (RPKM 56.1), Adrenal (RPKM 4.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (244398604..244571100, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (241741933..241911214, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (258025177..259150709, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143111 (e-PCR)
- UniSTS:232358

AU026370 (e-PCR)
- UniSTS:114347

BF409913 (e-PCR)
- UniSTS:249010

D2Got177 (e-PCR)
- UniSTS:113334

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sialyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ganglioside biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

Names: GD1 alpha synthase; GalNAc alpha-2,6-sialyltransferase V; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6 GalNAc alpha-2,6-sialyltransferase 5; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase V; sialyltransferase 7E

NP_001258290.1

EC 2.4.3.3

EC 2.4.99.-

XP_038958743.1

EC 2.4.3.3

EC 2.4.99.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271361.2 → NP_001258290.1 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

See identical proteins and their annotated locations for NP_001258290.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A9K3Y7N2, M0R986, Q6ZXY9

Related

ENSRNOP00000066049.2, ENSRNOT00000072899.4

Conserved Domains (1) summary

pfam00777
Location:91 → 312

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

244398604..244571100 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102815.2 → XP_038958743.1 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 isoform X1

Conserved Domains (1) summary

pfam00777
Location:95 → 276

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)