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    Il1r2 interleukin 1 receptor type 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il1r2provided by RGD
    Official Full Name
    interleukin 1 receptor type 2provided by RGD
    Primary source
    RGD:621147
    See related
    EnsemblRapid:ENSRNOG00000014378 AllianceGenome:RGD:621147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable interleukin-1 binding activity and interleukin-1 receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in aggressive periodontitis; esophageal cancer; lung cancer; and organ system cancer. Orthologous to human IL1R2 (interleukin 1 receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 18.1), Lung (RPKM 9.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il1r2 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (49879928..49920374)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42384280..42424726)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (46840646..46881241)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6A1, pseudogene 2 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene uncharacterized LOC120094675 Neighboring gene H3.3 histone A like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evidence of associations between cytokine gene polymorphisms and quality of life in patients with cancer and their family caregivers. Alexander K, et al. Oncol Nurs Forum, 2014 Sep. PMID 25158664
    2. Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA. Bristulf J, et al. Eur Cytokine Netw, 1994 May-Jun. PMID 7524717
    3. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Guo X, et al. Nat Med, 2018 Jul. PMID 29942094
    4. An Immune-Related Signature Predicts Survival in Patients With Lung Adenocarcinoma. Zhang M, et al. Front Oncol, 2019. PMID 31921619, Free PMC Article
    5. IL1R2 Polymorphisms are Associated with Increased Risk of Esophageal Cancer. Liu J, et al. Curr Mol Med, 2020. PMID 31744444

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
      Title: Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
    2. Adipose-Derived Extract Suppresses IL-1beta-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats.
      Title: Adipose-Derived Extract Suppresses IL-1β-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats.
    3. Activity of Il-1 in parturition is regulated by progesterone via Il1R1/Il1R2/Il-1RAcp pathway.
      Title: Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-1 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-1 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1, type II, blocking receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 alpha production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-1 alpha production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor type 2
    Names
    CD121 antigen-like family member B
    IL-1 type II receptor
    IL-1R-2
    IL-1R-beta
    IL-1RT-2
    IL-1RT2
    interleukin-1 receptor beta
    interleukin-1 receptor type II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053953.2 → NP_446405.1  interleukin-1 receptor type 2 precursor

      See identical proteins and their annotated locations for NP_446405.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P43303, Q5BJ99
      UniProtKB/TrEMBL
      A0A0H2UHL7, A6INM7
      Related
      ENSRNOP00000019415.4, ENSRNOT00000019415.7
      Conserved Domains (1) summary
      PHA02785
      Location:41 → 340
      PHA02785; IL-beta-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      49879928..49920374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082947.2 → XP_038938875.1  interleukin-1 receptor type 2 isoform X1

      Conserved Domains (1) summary
      PHA02785
      Location:59 → 310
      PHA02785; IL-beta-binding protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43303.1 GenPept UniProtKB/Swiss-Prot:P43303

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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