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    RT1-CE12 RT1 class I, locus CE12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309600, updated on 9-Dec-2024

    Summary

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    Symbol
    RT1-CE12provided by RGD
    Full Name
    RT1 class I, locus CE12provided by RGD
    Primary source
    RGD:1359103
    See related
    AllianceGenome:RGD:1359103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RT1.46
    Summary
    Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RT1-CE12 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3290831..3347349, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3338907..3342547, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108353253 Neighboring gene Cdk2ap1-ps8 pseudogene Neighboring gene RT1 class I, locus CE15 Neighboring gene uncharacterized LOC120098828 Neighboring gene LOC224733l-9 pseudogene Neighboring gene Cdk2ap1-ps7 pseudogene Neighboring gene RT1 class I, locus CE14 Neighboring gene RT1 class I, locus CE13 Neighboring gene uncharacterized LOC120098829 Neighboring gene Cdk2ap1-ps6 pseudogene Neighboring gene VPS52 subunit of GARP complex, pseudogene 7 Neighboring gene VPS52 subunit of GARP complex, pseudogene 6 Neighboring gene VPS52 subunit of GARP complex, pseudogene 5 Neighboring gene RT1 class I, locus CE11 Neighboring gene uncharacterized LOC120098832 Neighboring gene LOC224733l-8 pseudogene Neighboring gene Cdk2ap1-ps5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of five distinct cDNA clones encoding for class I RT1 antigens. Mauxion F, et al. Immunogenetics, 1989. PMID 2731966
    2. Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats. Dai KZ, et al. J Immunol, 2018 Apr 15. PMID 29531166, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    RT1 class I, locus CE12
    Names
    MHC RT44 protein
    MHC class I antigen
    RT1 class I histocompatibility antigen, AA alpha chain-like
    RT1 class I, CE12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008835.2 → NP_001008835.1  RT1 class I, locus CE12 precursor

      See identical proteins and their annotated locations for NP_001008835.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A2P1NRX5, Q6MG32
      Conserved Domains (3) summary
      cd07698
      Location:207 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:25 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:344 → 370
      MHC_I_C; MHC_I C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3290831..3347349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279095.1 → XP_063135165.1  RT1 class I, locus CE12 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4S5

    2. XM_063279094.1 → XP_063135164.1  RT1 class I, locus CE12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4S5

    3. XM_063279097.1 → XP_063135167.1  RT1 class I, locus CE12 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K4S5

    4. XM_063279096.1 → XP_063135166.1  RT1 class I, locus CE12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4S5

    5. XM_063279098.1 → XP_063135168.1  RT1 class I, locus CE12 isoform X5

      UniProtKB/TrEMBL
      O62933

    6. XM_063279099.1 → XP_063135169.1  RT1 class I, locus CE12 isoform X5

      UniProtKB/TrEMBL
      O62933

    RNA

    1. XR_010060667.1 RNA Sequence

    2. XR_010060666.1 RNA Sequence

    3. XR_010060664.1 RNA Sequence

    4. XR_010060665.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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