Galnt1 polypeptide N-acetylgalactosaminyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Galnt1provided by RGD
Official Full Name: polypeptide N-acetylgalactosaminyltransferase 1provided by RGD
Primary source: RGD:620358
See related: EnsemblRapid:ENSRNOG00000016207 AllianceGenome:RGD:620358
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 233.4), Spleen (RPKM 209.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (15763697..15843598)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (15489015..15568849)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (16141062..16187271)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the GalNAc-T1 lectin domain plays a critical role in enzymatic activity, and GalNAc-T1 has two activities distinguished by their sensitivities to inhibition with free GalNAc
Title: The lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 is involved in O-glycosylation of a polypeptide with multiple acceptor sites.
the lectin domain of GalNAc-T1 has at least two functional repeats, allowing the possibility of multivalent interactions with GalNAc residues on the acceptor polypeptide during glycosylation
Title: Function of the lectin domain of polypeptide N-acetylgalactosaminyltransferase 1.

Submit: New GeneRIF Correction

General gene information

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Markers

RH136793 (e-PCR)
- UniSTS:218882

BQ210126 (e-PCR)
- UniSTS:260698

GALNT1 (e-PCR)
- UniSTS:504251

RH132766 (e-PCR)
- UniSTS:216049

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables polypeptide N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables polypeptide N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables polypeptide N-acetylgalactosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables polypeptide N-acetylgalactosaminyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables polypeptide N-acetylgalactosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables polypeptide N-acetylgalactosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein O-linked glycosylation	TAS Traceable Author Statement more info	PubMed
involved_in protein O-linked glycosylation via serine	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation via threonine	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polypeptide N-acetylgalactosaminyltransferase 1

Names: UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); galNAc-T1; polypeptide GalNAc transferase 1; polypeptide GalNAc transferase T1; pp-GaNTase 1; protein-UDP acetylgalactosaminyltransferase 1

NP_077349.1

EC 2.4.1.41

XP_038953064.1

EC 2.4.1.41

XP_038953065.1

EC 2.4.1.41

XP_063133670.1

EC 2.4.1.41

XP_063133671.1

EC 2.4.1.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024373.2 → NP_077349.1 polypeptide N-acetylgalactosaminyltransferase 1

See identical proteins and their annotated locations for NP_077349.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q10473

UniProtKB/TrEMBL

A0A8I5ZUR3, A6J2K1

Conserved Domains (2) summary

cd02510
Location:119 → 419

pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

pfam00652
Location:432 → 548

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

15763697..15843598

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097137.2 → XP_038953065.1 polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q10473

UniProtKB/TrEMBL

A0A8I5ZUR3, A6J2K1

Conserved Domains (2) summary

cd02510
Location:119 → 419

pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

pfam00652
Location:432 → 548

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
XM_039097136.2 → XP_038953064.1 polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q10473

UniProtKB/TrEMBL

A0A8I5ZUR3, A6J2K1

Related

ENSRNOP00000022117.2, ENSRNOT00000022117.6

Conserved Domains (2) summary

cd02510
Location:119 → 419

pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

pfam00652
Location:432 → 548

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
XM_063277601.1 → XP_063133671.1 polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q10473

UniProtKB/TrEMBL

A0A8I5ZUR3, A6J2K1
XM_063277600.1 → XP_063133670.1 polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q10473

UniProtKB/TrEMBL

A0A8I5ZUR3, A6J2K1