Lypla1 lysophospholipase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lypla1provided by RGD
Official Full Name: lysophospholipase 1provided by RGD
Primary source: RGD:3025
See related: EnsemblRapid:ENSRNOG00000008320 AllianceGenome:RGD:3025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 25KDL; APT-1; LPL-I; Pla1a; lysoPLA
Summary: Enables lysophospholipase activity. Predicted to be involved in several processes, including negative regulation of Golgi to plasma membrane protein transport; negative regulation of aggrephagy; and protein depalmitoylation. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and nucleus. Predicted to be active in mitochondrion. Orthologous to human LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 694.6), Liver (RPKM 510.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (19477408..19506568, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (14679605..14708774, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (14559333..14588447, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results reveal that LysoPLA I catalyzes the removal of n-octanoic acid from ghrelin to form des-acyl ghrelin
Title: Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach.
activity in eosinophil leukocytes
Title: Phospholipase and lysophospholipase activity of rat eosinophil leukocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128529 (e-PCR)
- UniSTS:211837

RH132667 (e-PCR)
- UniSTS:215950

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-(protein) hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in macromolecule depalmitoylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of aggrephagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein depalmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein depalmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein depalmitoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: acyl-protein thioesterase 1

Names: lysoPLA I; lysophospholipase I; palmitoyl-protein hydrolase

NP_037138.1

EC 3.1.2.22

XP_038965233.1

EC 3.1.2.22

XP_038965234.1

EC 3.1.2.22

XP_038965236.1

EC 3.1.2.22

XP_063143256.1

EC 3.1.2.22

XP_063143257.1

EC 3.1.2.22

XP_063143258.1

EC 3.1.2.22

XP_063143259.1

EC 3.1.2.22

XP_063143260.1

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429408.1 → NP_001416337.1 acyl-protein thioesterase 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZTV1
NM_001429409.1 → NP_001416338.1 acyl-protein thioesterase 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZTV1
NM_001429410.1 → NP_001416339.1 acyl-protein thioesterase 1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5YBB3, A0A8I5ZTV1
NM_001429411.1 → NP_001416340.1 acyl-protein thioesterase 1 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZTV1
NM_001429412.1 → NP_001416341.1 acyl-protein thioesterase 1 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8L2Q511
NM_013006.3 → NP_037138.1 acyl-protein thioesterase 1 isoform 2

See identical proteins and their annotated locations for NP_037138.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P70470

UniProtKB/TrEMBL

A0A8I5ZTV1, A6JFJ3

Related

ENSRNOP00000011312.5, ENSRNOT00000011312.5

Conserved Domains (1) summary

pfam02230
Location:8 → 226

Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

19477408..19506568 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287189.1 → XP_063143259.1 acyl-protein thioesterase 1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZYI9
XM_063287188.1 → XP_063143258.1 acyl-protein thioesterase 1 isoform X5

UniProtKB/TrEMBL

A0A8I5ZYI9
XM_039109305.2 → XP_038965233.1 acyl-protein thioesterase 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZTV1, A0A8I6APY4

Conserved Domains (1) summary

pfam02230
Location:8 → 229

Abhydrolase_2; Phospholipase/Carboxylesterase
XM_063287190.1 → XP_063143260.1 acyl-protein thioesterase 1 isoform X7
XM_063287187.1 → XP_063143257.1 acyl-protein thioesterase 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZYI9
XM_039109306.2 → XP_038965234.1 acyl-protein thioesterase 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTV1

Related

ENSRNOP00000083839.2, ENSRNOT00000117962.2

Conserved Domains (1) summary

pfam02230
Location:8 → 213

Abhydrolase_2; Phospholipase/Carboxylesterase
XM_063287186.1 → XP_063143256.1 acyl-protein thioesterase 1 isoform X1
XM_039109308.2 → XP_038965236.1 acyl-protein thioesterase 1 isoform X8

Conserved Domains (1) summary

cl21494
Location:8 → 123

Abhydrolase; alpha/beta hydrolases