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    Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56011, updated on 27-Dec-2024

    Summary

    Official Symbol
    Ywhabprovided by RGD
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, betaprovided by RGD
    Primary source
    RGD:61998
    See related
    EnsemblRapid:ENSRNOG00000010945 AllianceGenome:RGD:61998
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including enzyme inhibitor activity; histone deacetylase binding activity; and phosphoserine residue binding activity. Involved in negative regulation of DNA-templated transcription. Part of transcription repressor complex. Used to study visual epilepsy. Biomarker of brain ischemia. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1151.6), Adrenal (RPKM 764.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ywhab in Genome Data Viewer
    Location:
    3q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173078904..173101508)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152659663..152682105)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160391108..160399931)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 15 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene serine/threonine kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoserine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoserine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    14-3-3 protein beta/alpha
    Names
    14-3-3 protein beta-subtype
    3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide
    KCIP-1
    prepronerve growth factor RNH-1
    protein kinase C inhibitor protein 1
    tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide
    tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
    tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
    tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019377.2NP_062250.1  14-3-3 protein beta/alpha

      See identical proteins and their annotated locations for NP_062250.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P35213
      UniProtKB/TrEMBL
      A0A8I6GMK2, A6JX54
      Related
      ENSRNOP00000097549.2, ENSRNOT00000118405.2
      Conserved Domains (1) summary
      cl02098
      Location:4232
      14-3-3; 14-3-3 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173078904..173101508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284421.1XP_063140491.1  14-3-3 protein beta/alpha isoform X1