Taf6 TATA-box binding protein associated factor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taf6provided by RGD
Official Full Name: TATA-box binding protein associated factor 6provided by RGD
Primary source: RGD:1311608
See related: EnsemblRapid:ENSRNOG00000001355 AllianceGenome:RGD:1311608
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TAFII70; TAF(II)80
Summary: Predicted to enable DNA binding activity; aryl hydrocarbon receptor binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in several processes, including positive regulation of intrinsic apoptotic signaling pathway; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MLL1 complex; transcription factor TFIID complex; and transcription factor TFTC complex. Predicted to be active in nucleus. Orthologous to human TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 139.4), Thymus (RPKM 127.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (22169570..22178031, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (17055864..17064244, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (19320269..19328706, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF406289 (e-PCR)
- UniSTS:248325

BI301666 (e-PCR)
- UniSTS:246885

RH137179 (e-PCR)
- UniSTS:219267

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables aryl hydrocarbon receptor binding	IEA Inferred from Electronic Annotation more info
enables aryl hydrocarbon receptor binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in mRNA transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MLL1 complex	IEA Inferred from Electronic Annotation more info
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SAGA complex	IEA Inferred from Electronic Annotation more info
part_of SLIK (SAGA-like) complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 6

Names: TAF(II)70; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kDa; TAFII-70; TAFII-80; TAFII80; TFIID subunit p80; p80; transcription initiation factor TFIID 70 kDa subunit; transcription initiation factor TFIID 80 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044225.1 → NP_001037690.1 transcription initiation factor TFIID subunit 6

Status: PROVISIONAL

Source sequence(s)

BC100108

UniProtKB/TrEMBL

Q498R0

Conserved Domains (1) summary

cd08050
Location:15 → 388

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

22169570..22178031 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271144.1 → XP_063127214.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

Q63801

UniProtKB/TrEMBL

A6KST3

Related

ENSRNOP00000001829.7, ENSRNOT00000001829.8
XM_063271145.1 → XP_063127215.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

Q63801

UniProtKB/TrEMBL

A6KST3
XM_063271146.1 → XP_063127216.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

Q63801

UniProtKB/TrEMBL

A6KST3