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    Pnoc prepronociceptin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pnocprovided by RGD
    Official Full Name
    prepronociceptinprovided by RGD
    Primary source
    RGD:3362
    See related
    EnsemblRapid:ENSRNOG00000014231 AllianceGenome:RGD:3362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    N23K; Npnc1
    Summary
    Predicted to enable opioid receptor binding activity and receptor ligand activity. Involved in chemical synaptic transmission; female pregnancy; and neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; neuronal cell body; and synaptic membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in neonatal abstinence syndrome. Orthologous to human PNOC (prepronociceptin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 75.9), Brain (RPKM 26.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pnoc in Genome Data Viewer
    Location:
    15p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43800240..43827841, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39624635..39652463, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48805841..48833071, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097019 Neighboring gene zinc finger protein 395 Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene annexin A2, pseudogene1 Neighboring gene ribosomal protein S17, pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunolocalization of orphanin FQ in rat cochlea. Kho ST, et al. Brain Res, 2006 Oct 3. PMID 16935273
    2. Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release. Marti M, et al. J Neurochem, 2004 Dec. PMID 15584926
    3. The role of ERK-1/2 in the N/OFQ-induced inhibition of delayed rectifier potassium currents. Wang W, et al. Biochem Biophys Res Commun, 2010 Apr 16. PMID 20331962
    4. Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats. Crisostomo MM, et al. J Appl Physiol (1985), 2005 Jun. PMID 15649868
    5. Nociceptin/orphanin FQ peptide in hypothalamic neurones associated with the control of feeding behaviour. Maolood N, et al. J Neuroendocrinol, 2010 Feb. PMID 20025627

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
      Title: Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
    2. An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food.
      Title: An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food.
    3. Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers.
      Title: Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.
    4. Nociceptin co-localized only with insulin in pancreatic beta cells.
      Title: Effect of nociceptin on insulin release in normal and diabetic rat pancreas.
    5. LPS-inoculation in rodents is an unsuitable model for studying possible changes in the NOP-N/OFQ system in sepsis.
      Title: Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system.
    6. Results suggest that CaMKII is involved in the inhibitory effect of N/OFQ on delayed rectifier potassium currents in acutely dissociated rat cerebral parietal cortical neurons
      Title: Nociceptin/orphanin FQ-induced inhibition of delayed rectifier potassium currents by calcium/calmodulin-dependent protein kinase type II.
    7. Estradiol negatively modulates the pleiotropic inhibitory actions of nociceptin.
      Title: Estradiol negatively modulates the pleiotropic actions of orphanin FQ/nociceptin at proopiomelanocortin synapses.
    8. These results suggest that N/OFQ can act directly in the nucleus accumbens shell to block cocaine-induced increases in extracellular dopamine levels
      Title: Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity.
    9. The findings suggest a link between N/OFQ and the development of hyperalgesia and allodynia in a rat model of PTSD.
      Title: Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD.
    10. The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
      Title: Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables opioid peptide activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables opioid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuron-neuron synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prepronociceptin
    Names
    Prepronociceptin (neuropeptide nociceptin) (N23K)
    neuropeptide nociceptin 1
    nociceptin
    orphanin FQ

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013007.1 → NP_037139.1  prepronociceptin precursor

      See identical proteins and their annotated locations for NP_037139.1

      Status: PROVISIONAL

      Source sequence(s)
      X97375
      UniProtKB/Swiss-Prot
      Q62923, Q64162
      UniProtKB/TrEMBL
      A6K6J8
      Related
      ENSRNOP00000019117.6, ENSRNOT00000019117.9
      Conserved Domains (1) summary
      pfam01160
      Location:21 → 66
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      43800240..43827841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093010.2 → XP_038948938.1  prepronociceptin isoform X1

      UniProtKB/TrEMBL
      A6K6J7
      Conserved Domains (1) summary
      pfam01160
      Location:21 → 66
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    2. XM_006252196.5 → XP_006252258.1  prepronociceptin isoform X1

      See identical proteins and their annotated locations for XP_006252258.1

      UniProtKB/TrEMBL
      A6K6J7
      Conserved Domains (1) summary
      pfam01160
      Location:21 → 66
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    3. XM_063273998.1 → XP_063130068.1  prepronociceptin isoform X2

      UniProtKB/Swiss-Prot
      Q62923, Q64162
      UniProtKB/TrEMBL
      A6K6J8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62923.1 GenPept UniProtKB/Swiss-Prot:Q62923

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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