Ptgs2 prostaglandin-endoperoxide synthase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgs2provided by RGD
Official Full Name: prostaglandin-endoperoxide synthase 2provided by RGD
Primary source: RGD:620349
See related: EnsemblRapid:ENSRNOG00000002525 AllianceGenome:RGD:620349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cox2; COX-2; PGHS-2; PHS II
Summary: Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in caveola and cytoplasm. Part of protein-containing complex. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); avian influenza; liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 161.3), Brain (RPKM 53.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (64714063..64722320)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (62163936..62172193)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (67351230..67356920)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COX2 expression plays a role in spinal cord injury-induced neuropathic pain.
Title: COX2 expression plays a role in spinal cord injury-induced neuropathic pain.
Electroacupuncture regulates microglial polarization via inhibiting NF-kappaB/COX2 pathway following traumatic brain injury.
Title: Electroacupuncture regulates microglial polarization via inhibiting NF-κB/COX2 pathway following traumatic brain injury.
Mineralocorticoid receptors contribute to ethanol-induced vascular hypercontractility through reactive oxygen species generation and up-regulation of cyclooxygenase 2.
Title: Mineralocorticoid receptors contribute to ethanol-induced vascular hypercontractility through reactive oxygen species generation and up-regulation of cyclooxygenase 2.
Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia.
Title: Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia.
Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.
Title: Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.
Contribution of cyclooxygenase-2 overexpression to enhancement in tonically active glutamatergic inputs to the rostral ventrolateral medulla in hypertension.
Title: Contribution of cyclooxygenase-2 overexpression to enhancement in tonically active glutamatergic inputs to the rostral ventrolateral medulla in hypertension.
Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats.
Title: Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats.
Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E2 receptor 1.
Title: Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E(2) receptor 1.
Prenatal Activation of Glucocorticoid Receptors Induces Memory Impairment in a Sex-Dependent Manner: Role of Cyclooxygenase-2.
Title: Prenatal Activation of Glucocorticoid Receptors Induces Memory Impairment in a Sex-Dependent Manner: Role of Cyclooxygenase-2.
Metabolic Profiling Implicates a Critical Role of Cyclooxygenase-2-Mediated Arachidonic Acid Metabolism in Radiation-Induced Esophageal Injury in Rats.
Title: Metabolic Profiling Implicates a Critical Role of Cyclooxygenase-2-Mediated Arachidonic Acid Metabolism in Radiation-Induced Esophageal Injury in Rats.

Submit: New GeneRIF Correction See all GeneRIFs (416)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC27868P2 (e-PCR)
- UniSTS:272389

Ptgs2 (e-PCR), detects polymorphism
- UniSTS:254306

Ptgs2 (e-PCR), detects polymorphism
- UniSTS:256486

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-endoperoxide synthase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin-endoperoxide synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ATP	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to homocysteine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to non-ionic osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in cyclooxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cyclooxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in cyclooxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in cyclooxygenase pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in decidualization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in hair cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fever generation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet-derived growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to nematode	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to selenium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to selenium ion	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostaglandin G/H synthase 2

Names: PGH synthase 2; cyclooxygenase-2; prostaglandin H2 synthase 2

NP_058928.3

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017232.4 → NP_058928.3 prostaglandin G/H synthase 2 precursor

See identical proteins and their annotated locations for NP_058928.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P35355, Q64379, Q925V4

UniProtKB/TrEMBL

A6ICR0, Q63124

Related

ENSRNOP00000003567.3, ENSRNOT00000003567.6

Conserved Domains (2) summary

cd09816
Location:75 → 562

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

pfam00008
Location:21 → 53

EGF; EGF-like domain