Egr3 early growth response 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Egr3provided by RGD
Official Full Name: early growth response 3provided by RGD
Primary source: RGD:2545
See related: EnsemblRapid:ENSRNOG00000017828 AllianceGenome:RGD:2545
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EGR-3
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; endothelial cell chemotaxis; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; and regulation of T cell differentiation. Predicted to be located in nucleoplasm and synapse. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 21.0), Spleen (RPKM 13.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (51560482..51565778)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (45150335..45156052)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (51756683..51762080)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGR3 regulates opioid-related nociception and motivation in male rats.
Title: EGR3 regulates opioid-related nociception and motivation in male rats.
Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia.
Title: Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia.
Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration.
Title: Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration.
Overexpression of EGR3 gene in an animal model of audiogenic seizures contributes to neuronal viability.
Title: Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures.
successfully created a rat model of schizophrenia by the transfection of EGR3 gene into rat brain. We then investigated the connectivity density of schizophrenia susceptible regions in rat brain using functional magnetic resonance imaging
Title: Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia.
Egr3 as a major regulator of gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4 in developing neurons and in epilepsy
Title: Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression.
Regulates levels of GABA-A receptors in response to brain-derived neurotrophic factor.
Title: Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peripheral nervous system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: early growth response protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017086.3 → NP_058782.1 early growth response protein 3

See identical proteins and their annotated locations for NP_058782.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P43301

UniProtKB/TrEMBL

A0A8I6A9R7, A6HTI6

Related

ENSRNOP00000095643.1, ENSRNOT00000094649.2

Conserved Domains (4) summary

COG5048
Location:303 → 375

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:277 → 299

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:275 → 299

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:319 → 344

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

51560482..51565778

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093001.2 → XP_038948929.1 early growth response protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I6A9R7, A0A8L2QCU2

Conserved Domains (2) summary

COG5048
Location:265 → 337

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:239 → 261

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006252240.5 → XP_006252302.1 early growth response protein 3 isoform X1

See identical proteins and their annotated locations for XP_006252302.1

UniProtKB/TrEMBL

A0A8I6A9R7, A0A8L2QCU2

Related

ENSRNOP00000024066.4, ENSRNOT00000024067.7

Conserved Domains (2) summary

COG5048
Location:265 → 337

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:239 → 261

ZF_C2H2; C2H2 Zn finger [structural motif]