Csnk1e casein kinase 1, epsilon [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csnk1eprovided by RGD
Official Full Name: casein kinase 1, epsilonprovided by RGD
Primary source: RGD:62045
See related: EnsemblRapid:ENSRNOG00000013076 AllianceGenome:RGD:62045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Multiple transcript variants have been detected for this gene, but their full-length natures have not been characterized. [provided by RefSeq, Feb 2014]
Expression: Biased expression in Lung (RPKM 105.2), Brain (RPKM 93.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112863726..112887338, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110983322..111006926, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120651976..120675559, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CK1epsilon drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/beta-catenin pathway.
Title: CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway.
Data show that casein kinases CSNK1D and CSNK1E inhibition resulted in rhythmic expression of clock genes in the liver, pancreas and suprachiasmatic nucleus.
Title: Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms.
Inhibition of casein kinase (CK)1epsilon induces a phase shift of locomotor activity toward daytime and prevents relapse-like alcohol drinking.
Title: Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking.
Csnk1delta/epsilon produces effects on behavior by acting on the signaling pathway that regulates AMPA receptor phosphorylation in the nucleus accumbens.
Title: Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129776 (e-PCR)
- UniSTS:213068

RH137940 (e-PCR)
- UniSTS:220027

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: casein kinase I

NP_113805.1

EC 2.7.11.1

XP_038935727.1

EC 2.7.11.1

XP_038935733.1

EC 2.7.11.1

XP_063120242.1

EC 2.7.11.1

XP_063120243.1

EC 2.7.11.1

XP_063120244.1

EC 2.7.11.1

XP_063120245.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031617.3 → NP_113805.1 casein kinase I

See identical proteins and their annotated locations for NP_113805.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZYG3, Q9JJ76

Related

ENSRNOP00000084410.2, ENSRNOT00000096240.2

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

112863726..112887338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079799.2 → XP_038935727.1 casein kinase I isoform X2

UniProtKB/TrEMBL

A0A8I5ZZ88

Related

ENSRNOP00000074993.2, ENSRNOT00000088424.3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_063264174.1 → XP_063120244.1 casein kinase I isoform X3

UniProtKB/TrEMBL

A0A8I5ZYG3, Q9JJ76
XM_039079805.2 → XP_038935733.1 casein kinase I isoform X5

UniProtKB/TrEMBL

A6HSR9, Q9JJ75

Related

ENSRNOP00000073559.1, ENSRNOT00000087800.3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_063264173.1 → XP_063120243.1 casein kinase I isoform X1

UniProtKB/TrEMBL

A0A8I5Y728
XM_063264172.1 → XP_063120242.1 casein kinase I isoform X1

UniProtKB/TrEMBL

A0A8I5Y728
XM_063264175.1 → XP_063120245.1 casein kinase I isoform X4