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    Nr2c1 nuclear receptor subfamily 2, group C, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nr2c1provided by RGD
    Official Full Name
    nuclear receptor subfamily 2, group C, member 1provided by RGD
    Primary source
    RGD:3200
    See related
    EnsemblRapid:ENSRNOG00000006983 AllianceGenome:RGD:3200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tr2; Psg4; TR2-11
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of retinoic acid receptor signaling pathway. Predicted to be located in PML body. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 44.6), Heart (RPKM 44.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nr2c1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30602338..30655610)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28715347..28768624)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35069807..35122810)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093556 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene U4 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene transmembrane and coiled-coil domain family 3 Neighboring gene uncharacterized LOC102554269

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C-mediated phosphorylation of orphan nuclear receptor TR2: effects on receptor stability and activity. Khan SA, et al. Proteomics, 2005 Oct. PMID 16130175
    2. The orphan nuclear receptor TR2 suppresses a DR4 hormone response element of the mouse CRABP-I gene promoter. Chinpaisal C, et al. Biochemistry, 1997 Nov 18. PMID 9369481
    3. Distinct expression patterns and biological activities of two isoforms of the mouse orphan receptor TR2. Lee CH, et al. J Endocrinol, 1997 Feb. PMID 9071982
    4. Molecular cloning and characterization of a mouse nuclear orphan receptor expressed in embryos and testes. Lee CH, et al. Mol Reprod Dev, 1996 Jul. PMID 8858600
    5. A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2. Yu Z, et al. J Endocrinol, 1998 Oct. PMID 9795341

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor subfamily 2 group C member 1
    Names
    nuclear receptor subfamily 2, group H, member 1
    orphan nuclear receptor TR2
    orphan receptor, TR2-11
    pregnancy specific beta-1-glycoprotein 4
    testicular receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145780.2 → NP_665723.1  nuclear receptor subfamily 2 group C member 1

      See identical proteins and their annotated locations for NP_665723.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q8VIJ4
      UniProtKB/TrEMBL
      A0A8L2R4T2
      Related
      ENSRNOP00000009578.1, ENSRNOT00000009578.6
      Conserved Domains (2) summary
      cd06952
      Location:355 → 576
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:96 → 182
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      30602338..30655610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078458.1 → XP_038934386.1  nuclear receptor subfamily 2 group C member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VIJ4
      UniProtKB/TrEMBL
      A0A8L2R4T2
      Conserved Domains (2) summary
      cd06952
      Location:355 → 576
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:96 → 182
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    2. XM_017594671.3 → XP_017450160.1  nuclear receptor subfamily 2 group C member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VIJ4
      UniProtKB/TrEMBL
      A0A8L2R4T2
      Conserved Domains (2) summary
      cd06952
      Location:355 → 576
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:96 → 182
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    3. XM_039078459.2 → XP_038934387.1  nuclear receptor subfamily 2 group C member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VIJ4
      UniProtKB/TrEMBL
      A0A8L2R4T2
      Related
      ENSRNOP00000071901.3, ENSRNOT00000089228.3
      Conserved Domains (2) summary
      cd06952
      Location:355 → 576
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:96 → 182
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RNA

    1. XR_005486547.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VIJ4.1 GenPept UniProtKB/Swiss-Prot:Q8VIJ4

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