Plxnb2 plexin B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plxnb2provided by RGD
Official Full Name: plexin B2provided by RGD
Primary source: RGD:1305495
See related: EnsemblRapid:ENSRNOG00000007133 AllianceGenome:RGD:1305495
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cell projection organization; and regulation of protein metabolic process. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Orthologous to human PLXNB2 (plexin B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 193.0), Liver (RPKM 141.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122111917..122138201, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120232276..120258385, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130135484..130161568, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH138860 (e-PCR)
- UniSTS:220947

D7Rat197 (e-PCR), detects polymorphism
- UniSTS:228145

BB195788 (e-PCR)
- UniSTS:209128

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108106.1 → NP_001101576.1 plexin-B2 precursor

See identical proteins and their annotated locations for NP_001101576.1

Status: PROVISIONAL

Source sequence(s)

CH474027

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1274 → 1808

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1068

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122111917..122138201 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263640.1 → XP_063119710.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_006242202.4 → XP_006242264.1 plexin-B2 isoform X1

See identical proteins and their annotated locations for XP_006242264.1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1274 → 1808

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1068

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_008765727.3 → XP_008763949.1 plexin-B2 isoform X1

See identical proteins and their annotated locations for XP_008763949.1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1274 → 1808

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1068

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006242207.4 → XP_006242269.1 plexin-B2 isoform X1

See identical proteins and their annotated locations for XP_006242269.1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1274 → 1808

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1068

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_063263643.1 → XP_063119713.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263645.1 → XP_063119715.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_039079305.2 → XP_038935233.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1274 → 1808

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1068

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_008765729.3 → XP_008763951.1 plexin-B2 isoform X1

See identical proteins and their annotated locations for XP_008763951.1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1274 → 1808

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1068

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_063263644.1 → XP_063119714.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263652.1 → XP_063119722.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263651.1 → XP_063119721.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263646.1 → XP_063119716.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263641.1 → XP_063119711.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263638.1 → XP_063119708.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263650.1 → XP_063119720.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263649.1 → XP_063119719.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263647.1 → XP_063119717.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263642.1 → XP_063119712.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57
XM_063263648.1 → XP_063119718.1 plexin-B2 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Y9, A6K7K6, D3ZQ57

Related

ENSRNOP00000072434.1, ENSRNOT00000088623.3