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    Mtch1 mitochondrial carrier 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtch1provided by RGD
    Official Full Name
    mitochondrial carrier 1provided by RGD
    Primary source
    RGD:1309262
    See related
    EnsemblRapid:ENSRNOG00000000527 AllianceGenome:RGD:1309262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable membrane insertase activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; and protein insertion into mitochondrial outer membrane. Predicted to be located in mitochondrial outer membrane. Predicted to be active in membrane and mitochondrion. Orthologous to human MTCH1 (mitochondrial carrier 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 825.1), Lung (RPKM 517.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtch1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7391558..7415291, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7389942..7413426, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6937341..6961165, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 6 open reading frame 89 Neighboring gene uncharacterized LOC120098949 Neighboring gene peptidase inhibitor 16 Neighboring gene uncharacterized LOC134483863 Neighboring gene FYVE, RhoGEF and PH domain containing 2 Neighboring gene uncharacterized LOC102547357 Neighboring gene uncharacterized LOC108349043

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. Xu X, et al. J Biol Chem, 2002 Dec 13. PMID 12377771
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial carrier homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100833.1 → NP_001094303.1  mitochondrial carrier homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_001094303.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158661
      UniProtKB/TrEMBL
      A0A1W2Q6G8, B0BN30
      Related
      ENSRNOP00000000635.4, ENSRNOT00000000635.8
      Conserved Domains (1) summary
      pfam00153
      Location:206 → 264
      Mito_carr; Mitochondrial carrier protein

    2. NM_001434572.1 → NP_001421501.1  mitochondrial carrier homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A1W2Q6G8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7391558..7415291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256184.3 → XP_006256246.1  mitochondrial carrier homolog 1 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:206 → 264
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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