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    Cep85 centrosomal protein 85 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362622, updated on 9-Dec-2024

    Summary

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    Symbol
    Cep85provided by RGD
    Full Name
    centrosomal protein 85provided by RGD
    Primary source
    RGD:1311520
    See related
    EnsemblRapid:ENSRNOG00000016249 AllianceGenome:RGD:1311520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc21; RGD1311520
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including centriole replication; negative regulation of protein kinase activity; and regulation of mitotic centrosome separation. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and nucleolus. Predicted to be active in centrosome. Orthologous to human CEP85 (centrosomal protein 85). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 145.1), Heart (RPKM 138.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep85 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151640316..151687891, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146356571..146404155, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152359693..152406530, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene UBX domain protein 11 Neighboring gene SH3 domain binding glutamate-rich protein like 3 Neighboring gene uncharacterized LOC134487003 Neighboring gene Uromoduilin-like Neighboring gene cation channel, sperm associated 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. Chen C, et al. J Cell Sci, 2015 Sep 1. PMID 26220856, Free PMC Article
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 85 kDa
    Names
    centrosomal protein 85kDa
    centrosomal protein of 85 kDa-like
    coiled-coil domain containing 21
    coiled-coil domain-containing protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395607.1 → NP_001382536.1  centrosomal protein of 85 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JUV7, A6IT07
      Related
      ENSRNOP00000069248.1, ENSRNOT00000078063.3
      Conserved Domains (1) summary
      COG1196
      Location:382 → 657
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151640316..151687891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764156.4 → XP_008762378.1  centrosomal protein of 85 kDa isoform X1

      See identical proteins and their annotated locations for XP_008762378.1

      UniProtKB/TrEMBL
      A0A0G2JUV7, A6IT07
      Conserved Domains (1) summary
      COG1196
      Location:382 → 657
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039110402.2 → XP_038966330.1  centrosomal protein of 85 kDa isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:302 → 563
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_008764157.4 → XP_008762379.1  centrosomal protein of 85 kDa isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:302 → 563
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_063288063.1 → XP_063144133.1  centrosomal protein of 85 kDa isoform X4

    5. XM_039110403.2 → XP_038966331.1  centrosomal protein of 85 kDa isoform X3

      UniProtKB/TrEMBL
      A1L1K5
      Conserved Domains (1) summary
      TIGR02168
      Location:337 → 543
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080151.1: Suppressed sequence

      Description
      NM_001080151.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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