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    Nrap nebulin-related anchoring protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrapprovided by RGD
    Official Full Name
    nebulin-related anchoring proteinprovided by RGD
    Primary source
    RGD:1306731
    See related
    EnsemblRapid:ENSRNOG00000016714 AllianceGenome:RGD:1306731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity; muscle alpha-actinin binding activity; and vinculin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in fascia adherens; muscle tendon junction; and myofibril. Predicted to be active in Z disc. Orthologous to human NRAP (nebulin related anchoring protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2415.4) and Heart (RPKM 812.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrap in Genome Data Viewer
    Location:
    1q55
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (265355324..265433229, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (255350113..255427704, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277104519..277181397, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100063 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene hyaluronan binding protein 2 Neighboring gene caspase 7 Neighboring gene pleckstrin homology domain containing S1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-RAP expression during mouse heart development. Lu S, et al. Dev Dyn, 2005 May. PMID 15765519
    2. Complete cDNA sequence and tissue localization of N-RAP, a novel nebulin-related protein of striated muscle. Luo G, et al. Cell Motil Cytoskeleton, 1997. PMID 9295142
    3. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Luo G, et al. Biochemistry, 1999 May 11. PMID 10320340
    4. New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly. Lu S, et al. J Cell Sci, 2003 Jun 1. PMID 12692149
    5. Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Zhang JQ, et al. Biochemistry, 2001 Dec 11. PMID 11732910

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables muscle alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables vinculin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle thin filament assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fascia adherens ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in muscle tendon junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nebulin-related-anchoring protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107443.2 → NP_001100913.2  nebulin-related-anchoring protein isoform C

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (C) has the same N- and C-termini but is shorter compared to isoform S.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A7A7
      Related
      ENSRNOP00000106373.1, ENSRNOT00000149841.1
      Conserved Domains (3) summary
      smart00227
      Location:485 → 515
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:6 → 58
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:313 → 339
      Nebulin; Nebulin repeat

    2. NM_001113743.1 → NP_001107215.1  nebulin-related-anchoring protein isoform S

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (S).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A7A7
      Related
      ENSRNOP00000086892.1, ENSRNOT00000115960.2
      Conserved Domains (3) summary
      smart00227
      Location:520 → 550
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:6 → 58
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:313 → 339
      Nebulin; Nebulin repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      265355324..265433229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110118.2 → XP_038966046.1  nebulin-related-anchoring protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6A7A7
      Conserved Domains (3) summary
      smart00227
      Location:521 → 551
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:6 → 58
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:562 → 589
      Nebulin; Nebulin repeat

    2. XM_006231644.5 → XP_006231706.1  nebulin-related-anchoring protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7A7, D4A4K6
      Related
      ENSRNOP00000030387.5, ENSRNOT00000038038.8
      Conserved Domains (3) summary
      smart00227
      Location:521 → 551
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:6 → 58
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:314 → 340
      Nebulin; Nebulin repeat

    3. XM_008760535.4 → XP_008758757.1  nebulin-related-anchoring protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7A7, D3Z802
      Related
      ENSRNOP00000029499.4, ENSRNOT00000038017.5
      Conserved Domains (3) summary
      smart00227
      Location:486 → 516
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:6 → 58
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:314 → 340
      Nebulin; Nebulin repeat

    4. XM_039110113.2 → XP_038966041.1  nebulin-related-anchoring protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6A7A7
      Related
      ENSRNOP00000106739.1, ENSRNOT00000128823.1
      Conserved Domains (3) summary
      smart00227
      Location:460 → 490
      NEBU; The Nebulin repeat is present also in Las1
      pfam00880
      Location:501 → 528
      Nebulin; Nebulin repeat
      cl02475
      Location:6 → 25
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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