Ppp1r15b protein phosphatase 1, regulatory subunit 15B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r15bprovided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 15Bprovided by RGD
Primary source: RGD:1307944
See related: EnsemblRapid:ENSRNOG00000028493 AllianceGenome:RGD:1307944
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein phosphatase regulator activity. Predicted to be involved in negative regulation of protein phosphorylation and response to endoplasmic reticulum stress. Predicted to act upstream of or within ER overload response and response to hydrogen peroxide. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Orthologous to human PPP1R15B (protein phosphatase 1 regulatory subunit 15B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 223.5), Adrenal (RPKM 219.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (47130000..47137805)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (44577840..44585737)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (49933155..49940961)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ER overload response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 1 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 15B

Names: protein phosphatase 1, regulatory (inhibitor) subunit 15b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107175.1 → NP_001100645.1 protein phosphatase 1 regulatory subunit 15B

See identical proteins and their annotated locations for NP_001100645.1

Status: PROVISIONAL

Source sequence(s)

CH473958

UniProtKB/TrEMBL

A6IC69, D3ZP67

Related

ENSRNOP00000034252.4, ENSRNOT00000037039.8

Conserved Domains (2) summary

pfam10472
Location:1 → 388

CReP_N; eIF2-alpha phosphatase phosphorylation constitutive repressor

pfam10488
Location:391 → 673

PP1c_bdg; Phosphatase-1 catalytic subunit binding region