Gprin1 G protein-regulated inducer of neurite outgrowth 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gprin1provided by RGD
Official Full Name: G protein-regulated inducer of neurite outgrowth 1provided by RGD
Primary source: RGD:1308762
See related: EnsemblRapid:ENSRNOG00000017974 AllianceGenome:RGD:1308762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphoprotein binding activity. Predicted to act upstream of or within neuron projection development. Predicted to be located in plasma membrane. Orthologous to human GPRIN1 (G protein regulated inducer of neurite outgrowth 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9869009..9881958)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9863881..9876832)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10411129..10415023)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha7 activation reduces hippocampal axon growth by coupling to Gprin1, which targets it to the growth cone. An alpha7/Gprin1 interaction is linked to a Galphao, growth-associated protein 43, and CDC42 cytoskeletal regulatory pathway within the developing axon.
Title: Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G protein-regulated inducer of neurite outgrowth 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.