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    Acot4 acyl-CoA thioesterase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acot4provided by RGD
    Official Full Name
    acyl-CoA thioesterase 4provided by RGD
    Primary source
    RGD:1596753
    See related
    EnsemblRapid:ENSRNOG00000046864 AllianceGenome:RGD:1596753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fatty acyl-CoA hydrolase activity and succinyl-CoA hydrolase activity. Predicted to be involved in carboxylic acid metabolic process and succinyl-CoA metabolic process. Predicted to be active in peroxisome. Orthologous to human ACOT4 (acyl-CoA thioesterase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 97.1), Liver (RPKM 90.9) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acot4 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109399032..109405138)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103668699..103674037)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107517668..107522952)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 1 Neighboring gene ribosomal protein L23A like 8 Neighboring gene acyl-CoA thioesterase 3 Neighboring gene acyl-CoA thioesterase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. Westin MA, et al. J Biol Chem, 2005 Nov 18. PMID 16141203
    2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
    3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
    4. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in butyrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dicarboxylic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dicarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in saturated monocarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in short-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in unsaturated monocarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase 4
    NP_001102910.1
    XP_038968847.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109440.2 → NP_001102910.1  acyl-coenzyme A thioesterase 4

      See identical proteins and their annotated locations for NP_001102910.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDS7, D3ZIQ1
      Related
      ENSRNOP00000013754.3, ENSRNOT00000013753.6
      Conserved Domains (2) summary
      pfam04775
      Location:17 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:203 → 412
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109399032..109405138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112919.2 → XP_038968847.2  acyl-coenzyme A thioesterase 4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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