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    Tbl1xr1 TBL1X/Y related 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbl1xr1provided by RGD
    Official Full Name
    TBL1X/Y related 1provided by RGD
    Primary source
    RGD:1560053
    See related
    EnsemblRapid:ENSRNOG00000011216 AllianceGenome:RGD:1560053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560053
    Summary
    Predicted to enable several functions, including beta-catenin binding activity; histone binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blastocyst hatching; fat pad development; and white fat cell differentiation. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Human ortholog(s) of this gene implicated in Pierpont syndrome and autosomal dominant intellectual developmental disorder 41. Orthologous to human TBL1XR1 (TBL1X/Y related 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 235.4), Spleen (RPKM 191.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbl1xr1 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (106718811..106857989)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (104788950..104929055)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (107221913..107359229)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100786 Neighboring gene spindlin-1-like Neighboring gene ribosomal protein L36, pseudogene Neighboring gene zinc finger protein 296, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue. Rohm M, et al. Cell Metab, 2013 Apr 2. PMID 23499424
    2. TBLR1 regulates the expression of nuclear hormone receptor co-repressors. Zhang XM, et al. BMC Cell Biol, 2006 Aug 7. PMID 16893456, Free PMC Article
    3. TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Li J, et al. Nat Cell Biol, 2008 Feb. PMID 18193033
    4. Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Ishii S, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18326024, Free PMC Article
    5. Reading and function of a histone code involved in targeting corepressor complexes for repression. Yoon HG, et al. Mol Cell Biol, 2005 Jan. PMID 15601853, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat pad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box-like/WD repeat-containing protein TBL1XR1
    Names
    TBL1X receptor 1
    transducin (beta)-like 1 X-linked receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108941.1 → NP_001102411.1  F-box-like/WD repeat-containing protein TBL1XR1

      See identical proteins and their annotated locations for NP_001102411.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473961
      UniProtKB/TrEMBL
      A6IHE1, D3ZNF4, G3V6G5
      Related
      ENSRNOP00000015573.4, ENSRNOT00000015573.6
      Conserved Domains (3) summary
      cd00200
      Location:164 → 470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:228 → 264
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      106718811..106857989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102745.1 → XP_038958673.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

      UniProtKB/TrEMBL
      A6IHE1, D3ZNF4, G3V6G5
      Conserved Domains (3) summary
      cd00200
      Location:164 → 470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:228 → 264
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH

    2. XM_039102747.1 → XP_038958675.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:77 → 383
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:141 → 177
      7WD40; WD40 repeat [structural motif]

    3. XM_006232190.4 → XP_006232252.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

      See identical proteins and their annotated locations for XP_006232252.1

      UniProtKB/TrEMBL
      A6IHE1, D3ZNF4, G3V6G5
      Conserved Domains (3) summary
      cd00200
      Location:164 → 470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:228 → 264
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH

    4. XM_039102748.1 → XP_038958676.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:77 → 383
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:141 → 177
      7WD40; WD40 repeat [structural motif]

    5. XM_039102746.2 → XP_038958674.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

      UniProtKB/TrEMBL
      A6IHE1, D3ZNF4, G3V6G5
      Conserved Domains (3) summary
      cd00200
      Location:164 → 470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:228 → 264
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH

    6. XM_017590991.3 → XP_017446480.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

      UniProtKB/TrEMBL
      A6IHE1, D3ZNF4, G3V6G5
      Conserved Domains (3) summary
      cd00200
      Location:164 → 470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:228 → 264
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH

    7. XM_017590990.2 → XP_017446479.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

      UniProtKB/TrEMBL
      A6IHE1, D3ZNF4, G3V6G5
      Conserved Domains (3) summary
      cd00200
      Location:164 → 470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:228 → 264
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH
    Nucleotide Protein Strain
    Heading Accession and Version

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