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    Zranb3 zinc finger RANBP2-type containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zranb3provided by RGD
    Official Full Name
    zinc finger RANBP2-type containing 3provided by RGD
    Primary source
    RGD:1564952
    See related
    EnsemblRapid:ENSRNOG00000003979 AllianceGenome:RGD:1564952
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564952
    Summary
    Predicted to enable ATP-dependent DNA/DNA annealing activity; DNA endonuclease activity; and K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear replication fork. Orthologous to human ZRANB3 (zinc finger RANBP2-type containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 59.6), Thymus (RPKM 33.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zranb3 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (41993110..42148298, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (39440653..39595782, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (44661375..44812430, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene microRNA 3473 Neighboring gene C-x(9)-C motif containing 1 like 1 Neighboring gene male-enhanced antigen 1-like Neighboring gene R3H domain containing 1 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. Yusufzai T, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21078962, Free PMC Article
    2. ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. Weston R, et al. Genes Dev, 2012 Jul 15. PMID 22759634, Free PMC Article
    3. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Ciccia A, et al. Mol Cell, 2012 Aug 10. PMID 22704558, Free PMC Article
    4. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Yuan J, et al. Mol Cell, 2012 Aug 10. PMID 22705370, Free PMC Article
    5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA rewinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork reversal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA annealing helicase and endonuclease ZRANB3
    Names
    zinc finger, RAN-binding domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      41993110..42148298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249701.5 → XP_006249763.1  DNA annealing helicase and endonuclease ZRANB3 isoform X1

      UniProtKB/TrEMBL
      D3ZDS8
      Related
      ENSRNOP00000103776.1, ENSRNOT00000125485.1
      Conserved Domains (6) summary
      smart00547
      Location:648 → 670
      ZnF_RBZ; Zinc finger domain
      smart00487
      Location:56 → 239
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:82 → 217
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00085
      Location:1014 → 1053
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:648 → 667
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00271
      Location:357 → 462
      Helicase_C; Helicase conserved C-terminal domain

    2. XM_008769510.4 → XP_008767732.1  DNA annealing helicase and endonuclease ZRANB3 isoform X4

      Conserved Domains (5) summary
      smart00547
      Location:266 → 288
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:10 → 122
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:632 → 671
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:266 → 285
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00271
      Location:1 → 80
      Helicase_C; Helicase conserved C-terminal domain

    3. XM_063272740.1 → XP_063128810.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

      UniProtKB/TrEMBL
      A6IBW5

    4. XM_039091286.2 → XP_038947214.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

      UniProtKB/TrEMBL
      A6IBW5
      Conserved Domains (4) summary
      smart00547
      Location:648 → 670
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:12 → 504
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      sd00029
      Location:648 → 667
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:64 → 283
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    5. XM_063272741.1 → XP_063128811.1  DNA annealing helicase and endonuclease ZRANB3 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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