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    Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef18provided by RGD
    Official Full Name
    Rho/Rac guanine nucleotide exchange factor 18provided by RGD
    Primary source
    RGD:1311448
    See related
    EnsemblRapid:ENSRNOG00000028090 AllianceGenome:RGD:1311448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly and protein localization to cell-cell junction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase-mediated signal transduction. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 116.6), Kidney (RPKM 91.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef18 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6192958..6300997)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1395035..1503082)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (1889252..1998128)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene insulin receptor Neighboring gene uncharacterized LOC134481143 Neighboring gene uncharacterized LOC134481144 Neighboring gene uncharacterized LOC120095867 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. Niu J, et al. Circ Res, 2003 Oct 31. PMID 14512443
    2. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article
    3. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Tornavaca O, et al. J Cell Biol, 2015 Mar 16. PMID 25753039, Free PMC Article
    4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 18
    Names
    rho/rac guanine nucleotide exchange factor (GEF) 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395655.2 → NP_001382584.2  rho guanine nucleotide exchange factor 18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZLL3

    2. NM_001429753.1 → NP_001416682.1  rho guanine nucleotide exchange factor 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZLL3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      6192958..6300997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271243.1 → XP_063127313.1  rho guanine nucleotide exchange factor 18 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLL3
      Related
      ENSRNOP00000062255.3, ENSRNOT00000066281.4

    2. XM_063271244.1 → XP_063127314.1  rho guanine nucleotide exchange factor 18 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLL3
      Related
      ENSRNOP00000099512.1, ENSRNOT00000148939.1

    3. XM_063271245.1 → XP_063127315.1  rho guanine nucleotide exchange factor 18 isoform X3

    4. XM_039089307.2 → XP_038945235.1  rho guanine nucleotide exchange factor 18 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLL3
      Conserved Domains (4) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:336 → 454
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:661 → 784
      DUF5401; Family of unknown function (DUF5401)
      cl28929
      Location:741 → 956
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107115.1: Suppressed sequence

      Description
      NM_001107115.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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