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    Emilin3 elastin microfibril interfacer 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Emilin3provided by RGD
    Official Full Name
    elastin microfibril interfacer 3provided by RGD
    Primary source
    RGD:1309607
    See related
    EnsemblRapid:ENSRNOG00000016734 AllianceGenome:RGD:1309607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in cytoplasm. Orthologous to human EMILIN3 (elastin microfibril interfacer 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 42.3), Adrenal (RPKM 15.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Emilin3 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (169978488..169984718, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (149558785..149564785, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (156899892..156906566, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene uncharacterized LOC134486198 Neighboring gene lipin 3 Neighboring gene chromodomain helicase DNA binding protein 6 Neighboring gene uncharacterized LOC134486200 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel gene, EMILIN-5, and its possible involvement in skeletal development. Doi M, et al. Biochem Biophys Res Commun, 2004 Jan 23. PMID 14706625
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EMILIN-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109901.2 → NP_001103371.1  EMILIN-3 precursor

      See identical proteins and their annotated locations for NP_001103371.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX00, D3ZQ65
      Related
      ENSRNOP00000101352.1, ENSRNOT00000147853.1
      Conserved Domains (2) summary
      pfam01442
      Location:467 → 646
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam07546
      Location:58 → 122
      EMI; EMI domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      169978488..169984718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235495.3 → XP_006235557.1  EMILIN-3 isoform X1

      Conserved Domains (2) summary
      pfam01442
      Location:414 → 593
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam07546
      Location:58 → 122
      EMI; EMI domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108602.1: Suppressed sequence

      Description
      NM_001108602.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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