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    Emilin2 elastin microfibril interfacer 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Emilin2provided by RGD
    Official Full Name
    elastin microfibril interfacer 2provided by RGD
    Primary source
    RGD:1305343
    See related
    EnsemblRapid:ENSRNOG00000014837 AllianceGenome:RGD:1305343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of blood coagulation; and positive regulation of platelet aggregation. Predicted to be located in extracellular region. Orthologous to human EMILIN2 (elastin microfibril interfacer 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 52.7), Heart (RPKM 51.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Emilin2 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (118607312..118667087, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (111160708..111220463, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (119594049..119653675, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2, pseudogene 1 Neighboring gene lipin 2 Neighboring gene U7 small nuclear RNA Neighboring gene structural maintenance of chromosomes flexible hinge domain containing 1 Neighboring gene Y box binding protein 1, pseudogene 8 Neighboring gene uncharacterized LOC134480432

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily. Doliana R, et al. J Biol Chem, 2001 Apr 13. PMID 11278945
    2. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. Soteriou D, et al. J Biol Chem, 2013 Jun 28. PMID 23658023, Free PMC Article
    3. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EMILIN-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431280.1 → NP_001418209.1  EMILIN-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6KFA0, F1LXD8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      118607312..118667087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084817.2 → XP_038940745.1  EMILIN-2 isoform X2

      UniProtKB/TrEMBL
      A6KFA0
      Conserved Domains (5) summary
      PHA03378
      Location:782 → 919
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:256 → 624
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01391
      Location:851 → 911
      Collagen; Collagen triple helix repeat (20 copies)
      pfam07546
      Location:49 → 117
      EMI; EMI domain
      cl23878
      Location:929 → 1067
      C1q; C1q domain

    2. XM_017596881.3 → XP_017452370.2  EMILIN-2 isoform X1

      Related
      ENSRNOP00000053111.5, ENSRNOT00000056272.6
      Conserved Domains (5) summary
      PHA03378
      Location:781 → 925
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:256 → 624
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01391
      Location:852 → 912
      Collagen; Collagen triple helix repeat (20 copies)
      pfam07546
      Location:49 → 117
      EMI; EMI domain
      cl23878
      Location:930 → 1068
      C1q; C1q domain

    3. XM_039084818.2 → XP_038940746.1  EMILIN-2 isoform X3

      UniProtKB/TrEMBL
      A6KFA0
      Related
      ENSRNOP00000107148.1, ENSRNOT00000174149.1
      Conserved Domains (4) summary
      PHA03378
      Location:653 → 797
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:128 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01391
      Location:724 → 784
      Collagen; Collagen triple helix repeat (20 copies)
      cl23878
      Location:802 → 940
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version

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