Mcoln2 mucolipin TRP cation channel 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcoln2provided by RGD
Official Full Name: mucolipin TRP cation channel 2provided by RGD
Primary source: RGD:1308884
See related: EnsemblRapid:ENSRNOG00000015089 AllianceGenome:RGD:1308884
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAADP-sensitive calcium-release channel activity and identical protein binding activity. Predicted to be involved in calcium-mediated signaling and iron ion transmembrane transport. Predicted to act upstream of or within myeloid leukocyte migration and positive regulation of chemokine production. Predicted to be located in recycling endosome. Predicted to be active in membrane. Orthologous to human MCOLN2 (mucolipin TRP cation channel 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 61.9), Kidney (RPKM 28.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (237714100..237762979)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (235053816..235102703)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (252018594..252068209)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134845 (e-PCR)
- UniSTS:218123

RH140948 (e-PCR)
- UniSTS:218123

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAADP-sensitive calcium-release channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables iron ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in iron ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage inflammatory protein 1 alpha production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
NOT is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
NOT is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucolipin-2

Names: mucolipin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039005.1 → NP_001034094.1 mucolipin-2

See identical proteins and their annotated locations for NP_001034094.1

Status: PROVISIONAL

Source sequence(s)

BC099787

UniProtKB/TrEMBL

A6HWD2, Q499S1

Related

ENSRNOP00000020452.5, ENSRNOT00000020452.8

Conserved Domains (1) summary

pfam08016
Location:380 → 513

PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

237714100..237762979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101881.2 → XP_038957809.1 mucolipin-2 isoform X1

UniProtKB/TrEMBL

A6HWD2

Conserved Domains (2) summary

pfam08016
Location:331 → 464

PKD_channel; Polycystin cation channel

cl41763
Location:62 → 226

ELD_TRPML; extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)