Sct secretin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sctprovided by RGD
Official Full Name: secretinprovided by RGD
Primary source: RGD:3643
See related: EnsemblRapid:ENSRNOG00000017873 AllianceGenome:RGD:3643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Secr
Summary: Enables digestive hormone activity. Involved in several processes, including intracellular water homeostasis; positive regulation of cAMP/PKA signal transduction; and regulation of secretion. Located in extracellular space. Orthologous to human SCT (secretin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 6.0), Spleen (RPKM 5.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205812435..205813246, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196382857..196383668, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214264865..214277437, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

propose that eyeblink conditioning (EBC)-induced secretin release from Purkinje cells modulates EBC acquisition by reducing surface expression of Kv1.2 at one or both of these sites
Title: Cerebellar secretin modulates eyeblink classical conditioning.
Secretin decreases cell surface Kv1.2 alpha-subunit levels by modulating Kv1.2 alpha- subunit endocytic trafficking.
Title: Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum.
Ursodeoxycholic acid is conjugated in order to promote secretin-stimulated hydrocholeresis in rats through Ae2, microtubules, intracellular Ca(2+), PKCalpha, PI3K, PKA, and MEK.
Title: Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat.
Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.
Title: Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.
Data show that in secretin/secretin receptor binding, the alpha-helix in natural secretin was oriented approximately parallel to the amino-terminal alpha-helix of the receptor.
Title: Importance of each residue within secretin for receptor binding and biological activity.
propose that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis
Title: Secretin as a neurohypophysial factor regulating body water homeostasis.
provide evidence of the endogenous release of secretin in the hypothalamus and the mechanisms underlying this release
Title: Endogenous release of secretin from the hypothalamus.
Atrial natriuretic factor may play a protective role by reducing secretin response to avoid overstimulation.
Title: Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas.
Secretin mRNA is present in gastric mucosa and the locally released secretin may exert a paracrine effect to inhibit acid secretion.
Title: Evidence on the presence of secretin cells in the gastric antral and oxyntic mucosa.
Solid evidence for the role of secretin as a neuropeptide in the mammalian central nervous system.
Title: Endogenous release and multiple actions of secretin in the rat cerebellum.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables digestive hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables digestive hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
involved_in diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in diet induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular water homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gastrin-induced gastric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gastrin-induced gastric acid secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of pancreatic juice secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pancreatic juice secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of somatostatin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of somatostatin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: secretin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.