Nmur2 neuromedin U receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nmur2provided by RGD
Official Full Name: neuromedin U receptor 2provided by RGD
Primary source: RGD:621155
See related: EnsemblRapid:ENSRNOG00000014081 AllianceGenome:RGD:621155
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FM-4; Nmu2r
Summary: Enables neuropeptide receptor activity. Involved in regulation of sensory perception of pain. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 154.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (40666824..40682679, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (40166223..40182078, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (41392663..41408518, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
Title: Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
NMUR2 is upregulated in bone cancer pain rat model. Short interference RNA NMUR2 alleviates nociception in bone cancer pain rat model.
Title: The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways.
This study shown that modulation of neuromedin U receptor 2 (NMUR2) in the paraventricular nucleus of the hypothalamus (PVN) results in increased food intake and motivation for energy-dense foods.
Title: Incubation of feeding behavior is regulated by neuromedin U receptor 2 in the paraventricular nucleus of the hypothalamus.
Results demonstrate that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods without disrupting feeding behavior associated with non-obesogenic standard chow
Title: Neuromedin U receptor 2 knockdown in the paraventricular nucleus modifies behavioral responses to obesogenic high-fat food and leads to increased body weight.
NMU and NMU receptor 2 compose a novel autocrine system in theca/interstitial cells in which the intensity of signaling is tightly controlled by gonadotropins.
Title: Ovarian regulation of neuromedin U and its local actions in the ovary, mediated through neuromedin U receptor 2.
Results show that central-activation of neuromedin U2 receptor markedly reduced sleep duration and disrupted the mechanisms underlying NREM-REM sleep transitions.
Title: Neuromedin U(2) receptor signaling mediates alteration of sleep-wake architecture in rats.
cultured rat calvarial osteoblast-like cells are provided with NMUR2, the receptor isoform typical for the central nervous system
Title: Neuromedin U directly stimulates growth of cultured rat calvarial osteoblast-like cells acting via the NMU receptor 2 isoform.
endogenous rat NmU receptors couple to both Galpha(q/11) and Galpha(i) G-proteins. Challenge of either circular or longitudinal rat isolated colonic smooth muscle. preparations with NmU resulted in robust contractions
Title: Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue.
These results suggest that NMU modulates the function of the PVN putative parvocellular neurons and is involved in the regulation of OTergic and VPergic neurons by enhanced HCN ion channels activity via NMU-receptor 2.
Title: Neuromedin U receptor-2 mRNA and HCN channels mRNA expression in NMU-sensitive neurons in rat hypothalamic paraventricular nucleus.
Expression of NMS and NMU2R genes was detected at the hypothalamus along postnatal development, with significant fluctuations of their relative levels (maximum at prepubertal stage and adulthood).
Title: Neuromedin s as novel putative regulator of luteinizing hormone secretion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046743 (e-PCR)
- UniSTS:111173

RH144592 (e-PCR)
- UniSTS:233837

AU027967 (e-PCR)
- UniSTS:112789

BM390633 (e-PCR)
- UniSTS:260833

D10Got62 (e-PCR)
- UniSTS:115683

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables neuromedin U binding	IEA Inferred from Electronic Annotation more info
enables neuromedin U binding	ISO Inferred from Sequence Orthology more info
enables neuromedin U receptor activity	IEA Inferred from Electronic Annotation more info
enables neuromedin U receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in grooming behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in reduction of food intake in response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reduction of food intake in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-U receptor 2

Names: G-protein coupled receptor TGR-1; G-protein-coupled receptor FM-4; NMU-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.