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    Pola2 DNA polymerase alpha 2, accessory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pola2provided by RGD
    Official Full Name
    DNA polymerase alpha 2, accessory subunitprovided by RGD
    Primary source
    RGD:621817
    See related
    EnsemblRapid:ENSRNOG00000020906 AllianceGenome:RGD:621817
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-directed DNA polymerase activity. Involved in DNA replication. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 81.3), Thymus (RPKM 73.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pola2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212656500..212680667, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203227183..203251350, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221297417..221321601, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 2 Neighboring gene 40S ribosomal protein S27-like Neighboring gene solute carrier family 22 member 20 Neighboring gene calpain 1 Neighboring gene uncharacterized LOC108349685

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. Popanda O, et al. Mol Carcinog, 2001 Aug. PMID 11536367
    2. The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase alpha. Mizuno T, et al. Mol Cell Biol, 1998 Jun. PMID 9584195, Free PMC Article
    3. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. López-Girona A, et al. Biochem Biophys Res Commun, 1995 Dec 14. PMID 7503737
    4. DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ. Baranovskiy AG, et al. J Biol Chem, 2012 May 18. PMID 22465957, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication, synthesis of primer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of alpha DNA polymerase:primase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of alpha DNA polymerase:primase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of alpha DNA polymerase:primase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of alpha DNA polymerase:primase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase alpha subunit B
    Names
    DNA polymerase alpha 70 kDa subunit
    DNA polymerase alpha subunit II
    DNA polymerase subunit II
    DNA-directed DNA polymerase alpha 2
    polymerase (DNA directed), alpha 2, accessory subunit
    polymerase (DNA) alpha 2, accessory subunit
    NP_445932.2
    XP_038948828.1
    XP_038948832.1
    XP_063131945.1
    XP_063131954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053480.2 → NP_445932.2  DNA polymerase alpha subunit B

      See identical proteins and their annotated locations for NP_445932.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097300
      UniProtKB/TrEMBL
      A6HZB5, G3V8U6, Q4V8M9
      Related
      ENSRNOP00000028406.3, ENSRNOT00000028406.6
      Conserved Domains (2) summary
      pfam04042
      Location:343 → 549
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:20 → 238
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212656500..212680667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092904.2 → XP_038948832.1  DNA polymerase alpha subunit B isoform X4

      Conserved Domains (1) summary
      pfam04042
      Location:56 → 262
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

    2. XM_063275884.1 → XP_063131954.1  DNA polymerase alpha subunit B isoform X2

    3. XM_063275875.1 → XP_063131945.1  DNA polymerase alpha subunit B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K567

    4. XM_039092900.2 → XP_038948828.1  DNA polymerase alpha subunit B isoform X3

      Conserved Domains (2) summary
      COG5214
      Location:206 → 411
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      pfam08418
      Location:21 → 238
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    RNA

    1. XR_010058450.1 RNA Sequence

    2. XR_001835495.3 RNA Sequence

    3. XR_005493542.2 RNA Sequence

    4. XR_005493528.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89043.2 GenPept UniProtKB/Swiss-Prot:O89043

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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