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    Opcml opioid binding protein/cell adhesion molecule-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Opcmlprovided by RGD
    Official Full Name
    opioid binding protein/cell adhesion molecule-likeprovided by RGD
    Primary source
    RGD:620635
    See related
    EnsemblRapid:ENSRNOG00000023809 AllianceGenome:RGD:620635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cell adhesion. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 337.9), Spleen (RPKM 53.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Opcml in Genome Data Viewer
    Location:
    8q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (34451629..35562897)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (26788988..27304551)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (28842202..29967300)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480005 Neighboring gene spermatogenesis associated 19 Neighboring gene endothelial differentiation-related factor 1, pseudogene 1 Neighboring gene uncharacterized LOC120094318 Neighboring gene uncharacterized LOC134480150 Neighboring gene neurotrimin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. OBCAM, an immunoglobulin superfamily cell adhesion molecule, regulates morphology and proliferation of cerebral astrocytes. Sugimoto C, et al. J Neurochem, 2010 Feb. PMID 19943852
    2. Dendrite-associated opioid-binding cell adhesion molecule localizes at neurosecretory granules in the hypothalamic magnocellular neurons. Miyata S, et al. Neuroscience, 2003. PMID 14596858
    3. Opioid-binding cell adhesion molecule (OBCAM)-related clones from a rat brain cDNA library. Lippman DA, et al. Gene, 1992 Aug 15. PMID 1339369
    4. Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain. Miyata S, et al. Neuroscience, 2003. PMID 12617969
    5. Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules. Struyk AF, et al. J Neurosci, 1995 Mar. PMID 7891157, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results of this study suggested that OBCAM is responsible for controlling the cell proliferation and growth in cortical astrocytes
      Title: OBCAM, an immunoglobulin superfamily cell adhesion molecule, regulates morphology and proliferation of cerebral astrocytes.
    2. OBCAM is synthesized within the somata, attached to vasopressin neurosecretory granules, and transported to the dendrites. The subcellular localization of OBCAM is changed in an activity-dependent manner.
      Title: Dendrite-associated opioid-binding cell adhesion molecule localizes at neurosecretory granules in the hypothalamic magnocellular neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    opioid-binding protein/cell adhesion molecule
    Names
    OBCAM
    opioid-binding cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053848.2 → NP_446300.2  opioid-binding protein/cell adhesion molecule precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P32735, P32736, Q01653, Q01654
      UniProtKB/TrEMBL
      A0A8I6A2A2, A6JYE6
      Related
      ENSRNOP00000103226.1, ENSRNOT00000137975.1
      Conserved Domains (3) summary
      pfam13927
      Location:223 → 300
      Ig_3; Immunoglobulin domain
      cd00096
      Location:224 → 230
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      34451629..35562897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264778.1 → XP_063120848.1  opioid-binding protein/cell adhesion molecule isoform X3

      UniProtKB/Swiss-Prot
      P32735, P32736, Q01653, Q01654

    2. XM_063264779.1 → XP_063120849.1  opioid-binding protein/cell adhesion molecule isoform X5

      UniProtKB/Swiss-Prot
      P32735, P32736, Q01653, Q01654
      UniProtKB/TrEMBL
      A0A0G2K657, A6JYE4
      Related
      ENSRNOP00000073684.2, ENSRNOT00000090643.3

    3. XM_063264780.1 → XP_063120850.1  opioid-binding protein/cell adhesion molecule isoform X6

      UniProtKB/Swiss-Prot
      P32735, P32736, Q01653, Q01654

    4. XM_017595412.3 → XP_017450901.1  opioid-binding protein/cell adhesion molecule isoform X1

      UniProtKB/Swiss-Prot
      P32735, P32736, Q01653, Q01654
      Conserved Domains (3) summary
      pfam13927
      Location:223 → 300
      Ig_3; Immunoglobulin domain
      cd00096
      Location:224 → 230
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    5. XM_017595413.3 → XP_017450902.1  opioid-binding protein/cell adhesion molecule isoform X2

      UniProtKB/Swiss-Prot
      P32735, P32736, Q01653, Q01654
      Related
      ENSRNOP00000110858.1, ENSRNOT00000157922.1
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    6. XM_017595415.3 → XP_017450904.1  opioid-binding protein/cell adhesion molecule isoform X4

      UniProtKB/Swiss-Prot
      P32735, P32736, Q01653, Q01654
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32736.2 GenPept UniProtKB/Swiss-Prot:P32736

    Gene LinkOut

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