U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cryba2 crystallin, beta A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286925, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cryba2provided by RGD
    Official Full Name
    crystallin, beta A2provided by RGD
    Primary source
    RGD:628768
    See related
    EnsemblRapid:ENSRNOG00000017996 AllianceGenome:RGD:628768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Human ortholog(s) of this gene implicated in cataract 42. Orthologous to human CRYBA2 (crystallin beta A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 2.0), Testes (RPKM 1.7) and 4 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cryba2 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83895921..83906651, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76447250..76457968, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82151056..82154266, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 5 regulatory subunit 2 Neighboring gene FEV transcription factor, ETS family member Neighboring gene uncharacterized LOC134480387 Neighboring gene microRNA 375 Neighboring gene cilia and flagella associated protein 65 Neighboring gene uncharacterized LOC102549980 Neighboring gene Indian hedgehog signaling molecule

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts. Puk O, et al. Invest Ophthalmol Vis Sci, 2011 Apr 20. PMID 21212184
    2. Energetics of domain-domain interactions and entropy driven association of beta-crystallins. Sergeev YV, et al. Biochemistry, 2004 Jan 20. PMID 14717595
    3. Identification of the human beta A2 crystallin gene (CRYBA2): localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1. Hulsebos TJ, et al. Genomics, 1995 Aug 10. PMID 7490092
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-crystallin A2
    Names
    betaA2-crystallin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431815.1 → NP_001418744.1  beta-crystallin A2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7ET28, Q8CGQ0

    2. NM_173140.2 → NP_775163.1  beta-crystallin A2

      See identical proteins and their annotated locations for NP_775163.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7ET28, Q8CGQ0
      Related
      ENSRNOP00000024283.3, ENSRNOT00000024283.5
      Conserved Domains (1) summary
      pfam00030
      Location:14 → 98
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83895921..83906651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266744.1 → XP_063122814.1  beta-crystallin A2 isoform X1

    2. XM_063266746.1 → XP_063122816.1  beta-crystallin A2 isoform X3

    3. XM_063266743.1 → XP_063122813.1  beta-crystallin A2 isoform X1

    4. XM_063266745.1 → XP_063122815.1  beta-crystallin A2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools