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    Pwwp2b PWWP domain containing 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pwwp2bprovided by RGD
    Official Full Name
    PWWP domain containing 2Bprovided by RGD
    Primary source
    RGD:1307108
    See related
    EnsemblRapid:ENSRNOG00000036649 AllianceGenome:RGD:1307108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pwwp2
    Summary
    Predicted to enable NuRD complex binding activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of cold-induced thermogenesis. Predicted to be located in nucleoplasm. Orthologous to human PWWP2B (PWWP domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 127.5), Lung (RPKM 62.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pwwp2b in Genome Data Viewer
    Location:
    1q41
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203470172..203489575)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194040395..194059979)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211579706..211600715)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 32C Neighboring gene uncharacterized LOC120099954 Neighboring gene leucine rich repeat containing 27 Neighboring gene uncharacterized LOC134485192 Neighboring gene uncharacterized LOC134485193 Neighboring gene uncharacterized LOC134485195

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NuRD complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PWWP domain-containing protein 2B
    Names
    PWWP domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108507.2 → NP_001101977.1  PWWP domain-containing protein 2B

      See identical proteins and their annotated locations for NP_001101977.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162015
      UniProtKB/TrEMBL
      A0A8I5ZP22, B1WC60

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      203470172..203489575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230466.5 → XP_006230528.1  PWWP domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZP22, F7FFV6
      Related
      ENSRNOP00000023619.6, ENSRNOT00000023619.7
      Conserved Domains (1) summary
      cd05835
      Location:499 → 584
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

    2. XM_063267951.1 → XP_063124021.1  PWWP domain-containing protein 2B isoform X2

    RNA

    1. XR_010054906.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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