Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r14bprovided by RGD
Official Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 14Bprovided by RGD
Primary source: RGD:628702
See related: AllianceGenome:RGD:628702
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PHI-1
Summary: Enables phosphatase inhibitor activity and protein phosphatase regulator activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm and membrane. Orthologous to human PPP1R14B (protein phosphatase 1 regulatory inhibitor subunit 14B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 495.2), Thymus (RPKM 494.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213594416..213596527)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204165210..204167320)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222229835..222231945)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PHI-1 participates in regulatory events at the trailing edge of migrating cells and modulates retraction of endothelial and epithelial cells
Title: Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein.
ILK may activate smooth-muscle contraction both directly, via phosphorylation of myosin, and indirectly, via phosphorylation and activation of CPI-17 and PHI-1, leading to inhibition of myosin light-chain phosphatase.
Title: Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 14B

Names: phosphatase holoenzyme inhibitor 1; protein phosphatase 1, regulatory (inhibitor) 5 subunit 14B; ubiquitous PKC-potentiated PP1 inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172045.1 → NP_742042.1 protein phosphatase 1 regulatory subunit 14B

See identical proteins and their annotated locations for NP_742042.1

Status: PROVISIONAL

Source sequence(s)

AY122323

UniProtKB/Swiss-Prot

Q8K3F3

UniProtKB/TrEMBL

A0A8I6G618

Conserved Domains (1) summary

pfam05361
Location:51 → 147

PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor