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    Hapln2 hyaluronan and proteoglycan link protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hapln2provided by RGD
    Official Full Name
    hyaluronan and proteoglycan link protein 2provided by RGD
    Primary source
    RGD:621854
    See related
    EnsemblRapid:ENSRNOG00000018870 AllianceGenome:RGD:621854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bral1
    Summary
    Predicted to enable hyaluronic acid binding activity. Predicted to be involved in nervous system development; positive regulation of neuroblast proliferation; and skeletal system development. Predicted to act upstream of or within establishment of blood-nerve barrier and extracellular matrix assembly. Predicted to be located in extracellular matrix and node of Ranvier. Predicted to be active in extracellular space; perineuronal net; and synapse. Orthologous to human HAPLN2 (hyaluronan and proteoglycan link protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 76.7) and Uterus (RPKM 2.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hapln2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175786767..175794515, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173488909..173496824, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187395104..187402076, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nestin Neighboring gene brevican Neighboring gene G patch domain containing 4 Neighboring gene NAD(P)HX epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bral1: its role in diffusion barrier formation and conduction velocity in the CNS. Bekku Y, et al. J Neurosci, 2010 Feb 24. PMID 20181608, Free PMC Article
    2. Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. Oohashi T, et al. Mol Cell Neurosci, 2002 Jan. PMID 11817897
    3. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Hirakawa S, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027579
    4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of blood-nerve barrier IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of blood-nerve barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in node of Ranvier IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in node of Ranvier ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perineuronal net IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hyaluronan and proteoglycan link protein 2
    Names
    brain link protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022285.2 → NP_071621.2  hyaluronan and proteoglycan link protein 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9ESM2
      UniProtKB/TrEMBL
      A6J644, G3V8G6
      Related
      ENSRNOP00000025624.4, ENSRNOT00000025624.9
      Conserved Domains (4) summary
      cd03518
      Location:149 → 242
      Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd03519
      Location:251 → 338
      Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd00096
      Location:46 → 48
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:46 → 151
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175786767..175794515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761209.4 → XP_008759431.1  hyaluronan and proteoglycan link protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008759431.1

      UniProtKB/Swiss-Prot
      Q9ESM2
      UniProtKB/TrEMBL
      A6J644, G3V8G6
      Conserved Domains (4) summary
      cd03518
      Location:149 → 242
      Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd03519
      Location:251 → 338
      Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd00096
      Location:46 → 48
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:46 → 151
      Ig; Immunoglobulin domain

    2. XM_006232751.5 → XP_006232813.1  hyaluronan and proteoglycan link protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006232813.1

      UniProtKB/Swiss-Prot
      Q9ESM2
      UniProtKB/TrEMBL
      A6J644, G3V8G6
      Conserved Domains (4) summary
      cd03518
      Location:149 → 242
      Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd03519
      Location:251 → 338
      Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd00096
      Location:46 → 48
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:46 → 151
      Ig; Immunoglobulin domain

    3. XM_017591067.3 → XP_017446556.1  hyaluronan and proteoglycan link protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9ESM2
      UniProtKB/TrEMBL
      A6J644, G3V8G6
      Conserved Domains (4) summary
      cd03518
      Location:149 → 242
      Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd03519
      Location:251 → 338
      Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd00096
      Location:46 → 48
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:46 → 151
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESM2.1 GenPept UniProtKB/Swiss-Prot:Q9ESM2

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