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    Mzt2b mitotic spindle organizing protein 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mzt2bprovided by RGD
    Official Full Name
    mitotic spindle organizing protein 2Bprovided by RGD
    Primary source
    RGD:1308126
    See related
    EnsemblRapid:ENSRNOG00000066842 AllianceGenome:RGD:1308126
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam128b; RGD1308126
    Summary
    Predicted to be located in cytosol and nucleoplasm. Predicted to be active in centrosome and spindle. Orthologous to several human genes including MZT2A (mitotic spindle organizing protein 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 48.1), Thymus (RPKM 47.7) and 9 other tissues See more
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    Genomic context

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    See Mzt2b in Genome Data Viewer
    Location:
    11q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (98528236..98535340)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (85024120..85031960)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (89276869..89283939)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene CCAAT/enhancer binding protein delta Neighboring gene scaffold protein involved in DNA repair Neighboring gene uncharacterized LOC134481106 Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene minichromosome maintenance complex component 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitotic-spindle organizing protein 2B
    Names
    family with sequence similarity 128, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105860.1 → NP_001099330.1  mitotic-spindle organizing protein 2B

      See identical proteins and their annotated locations for NP_001099330.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A0A8I5ZVW0, A6JSR4
      Conserved Domains (1) summary
      pfam12926
      Location:15 → 97
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      98528236..98535340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248731.5 → XP_006248793.1  mitotic-spindle organizing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006248793.1

      UniProtKB/TrEMBL
      A0A8I5ZVW0, A6JSR4
      Conserved Domains (1) summary
      pfam12926
      Location:15 → 97
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    2. XM_006248730.5 → XP_006248792.1  mitotic-spindle organizing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006248792.1

      UniProtKB/TrEMBL
      A0A8I5ZVW0, A6JSR4
      Related
      ENSRNOP00000082783.2, ENSRNOT00000115744.2
      Conserved Domains (1) summary
      pfam12926
      Location:15 → 97
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    3. XM_039088059.2 → XP_038943987.1  mitotic-spindle organizing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVW0, A6JSR4
      Conserved Domains (1) summary
      pfam12926
      Location:15 → 97
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    4. XM_006248729.3 → XP_006248791.1  mitotic-spindle organizing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006248791.1

      UniProtKB/TrEMBL
      A0A8I5ZVW0, A6JSR4
      Conserved Domains (1) summary
      pfam12926
      Location:15 → 97
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    5. XM_039088058.2 → XP_038943986.1  mitotic-spindle organizing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVW0, A6JSR4
      Conserved Domains (1) summary
      pfam12926
      Location:15 → 97
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated
    Nucleotide Protein Strain
    Heading Accession and Version

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