Gstm5l glutathione S-transferase, mu 5-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gstm5lprovided by RGD
Official Full Name: glutathione S-transferase, mu 5-likeprovided by RGD
Primary source: RGD:1311731
See related: EnsemblRapid:ENSRNOG00000060939 AllianceGenome:RGD:1311731
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gstm6l
Summary: Predicted to enable glutathione transferase activity and identical protein binding activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytosol and intercellular bridge. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 119.6), Testes (RPKM 68.5) and 7 other tissues See more
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198231285..198238122, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195544424..195549895, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210698155..210703265, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gstm6 (e-PCR), detects polymorphism
- UniSTS:526847

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase, mu 5-like; glutathione S-transferase, mu 6-like

Names: glutathione S-transferase M6-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106464.1 → NP_001099934.1 glutathione S-transferase, mu 5-like

See identical proteins and their annotated locations for NP_001099934.1

Status: PROVISIONAL

Source sequence(s)

CH473952

UniProtKB/TrEMBL

A0A8I6AJ43, A6HUV9

Conserved Domains (3) summary

cd03209
Location:58 → 175

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

COG0625
Location:26 → 155

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cl00388
Location:1 → 50

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198231285..198238122 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102079.2 → XP_038958007.1 glutathione S-transferase, mu 6-like isoform X1

UniProtKB/TrEMBL

A0A0G2K6L4, A0A8I6AJ43

Related

ENSRNOP00000098617.2, ENSRNOT00000121075.2

Conserved Domains (2) summary

cd03209
Location:92 → 209

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...