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    Stard3 StAR-related lipid transfer domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stard3provided by RGD
    Official Full Name
    StAR-related lipid transfer domain containing 3provided by RGD
    Primary source
    RGD:1549768
    See related
    EnsemblRapid:ENSRNOG00000042044 AllianceGenome:RGD:1549768
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity and protein homodimerization activity. Predicted to be involved in cholesterol transport and vesicle tethering to endoplasmic reticulum. Predicted to act upstream of or within progesterone biosynthetic process. Predicted to be located in several cellular components, including endosome; nucleoplasm; and organelle membrane contact site. Predicted to be active in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Orthologous to human STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 107.8), Kidney (RPKM 80.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stard3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83853622..83876162)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83357329..83379873)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86313430..86335868)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene neuronal differentiation 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B Neighboring gene titin-cap Neighboring gene phenylethanolamine-N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of cDNA clones from an osteosarcoma-ROS17/2.8 library by differential hybridization. Waye MM, et al. J Cell Biochem, 1994 Mar. PMID 8200907
    2. Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. Kishida T, et al. J Biol Chem, 2004 Apr 30. PMID 14963026
    3. STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. Wilhelm LP, et al. EMBO J, 2017 May 15. PMID 28377464, Free PMC Article
    4. Functional characterization of the MENTAL domain. Alpy F, et al. J Biol Chem, 2005 May 6. PMID 15718238
    5. STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. Alpy F, et al. J Cell Sci, 2013 Dec 1. PMID 24105263

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within progesterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 3
    Names
    START domain containing 3
    StAR-related lipid transfer (START) domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014229.1 → NP_001014251.1  stAR-related lipid transfer protein 3

      See identical proteins and their annotated locations for NP_001014251.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085872
      UniProtKB/TrEMBL
      A0A9K3Y7H2, F1M1S3, Q5U2T5
      Related
      ENSRNOP00000098266.1, ENSRNOT00000120631.2
      Conserved Domains (2) summary
      cd08906
      Location:234 → 442
      START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
      pfam10457
      Location:48 → 214
      MENTAL; Cholesterol-capturing domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83853622..83876162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086506.2 → XP_038942434.1  stAR-related lipid transfer protein 3 isoform X2

      Conserved Domains (2) summary
      pfam10457
      Location:48 → 214
      MENTAL; Cholesterol-capturing domain
      cl14643
      Location:234 → 266
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. XM_039086505.2 → XP_038942433.1  stAR-related lipid transfer protein 3 isoform X1

      UniProtKB/TrEMBL
      A6HIR9
      Conserved Domains (2) summary
      cd08906
      Location:186 → 394
      START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
      pfam10457
      Location:29 → 166
      MENTAL; Cholesterol-capturing domain
    Nucleotide Protein Strain
    Heading Accession and Version

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