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    Mmd monocyte to macrophage differentiation-associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303439, updated on 9-Dec-2024

    Summary

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    Symbol
    Mmdprovided by RGD
    Full Name
    monocyte to macrophage differentiation-associatedprovided by RGD
    Primary source
    RGD:1592079
    See related
    EnsemblRapid:ENSRNOG00000002436 AllianceGenome:RGD:1592079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Maf
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of neuron differentiation; positive regulation of protein kinase activity; and regulation of protein localization. Predicted to be located in Golgi apparatus. Orthologous to human MMD (monocyte to macrophage differentiation associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 251.8), Kidney (RPKM 127.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmd in Genome Data Viewer
    Location:
    10q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75570366..75598610)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (75073278..75101528)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (77687964..77783737)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693415 Neighboring gene small integral membrane protein 36 Neighboring gene uncharacterized LOC134480710 Neighboring gene uncharacterized LOC134480714 Neighboring gene HLF transcription factor, PAR bZIP family member Neighboring gene uncharacterized LOC134480636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells. Bräuer AU, et al. FEBS Lett, 2004 Apr 9. PMID 15063720
    2. Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study. Eudy AM, et al. Lupus, 2019 Dec. PMID 31684818, Free PMC Article
    3. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Jin T, et al. Cell Res, 2012 Apr. PMID 21968647, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94095

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pore-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    monocyte to macrophage differentiation factor
    Names
    macrophage/microglia activation-associated factor
    monocyte to macrophage differentiation protein
    progestin and adipoQ receptor family member 11
    progestin and adipoQ receptor family member XI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007673.1 → NP_001007674.1  monocyte to macrophage differentiation factor

      See identical proteins and their annotated locations for NP_001007674.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081965
      UniProtKB/Swiss-Prot
      Q719N3
      UniProtKB/TrEMBL
      A0A0H2UHA9
      Related
      ENSRNOP00000075635.1, ENSRNOT00000087765.3
      Conserved Domains (1) summary
      TIGR01065
      Location:27 → 227
      hlyIII; channel protein, hemolysin III family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      75570366..75598610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086052.2 → XP_038941980.1  monocyte to macrophage differentiation factor isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHA9
      Conserved Domains (1) summary
      cl03831
      Location:27 → 202
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q719N3.1 GenPept UniProtKB/Swiss-Prot:Q719N3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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