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    Txnl4a thioredoxin-like 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Txnl4aprovided by RGD
    Official Full Name
    thioredoxin-like 4Aprovided by RGD
    Primary source
    RGD:6492735
    See related
    EnsemblRapid:ENSRNOG00000057774 AllianceGenome:RGD:6492735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Txnl4
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in Burn-McKeown syndrome. Orthologous to human TXNL4A (thioredoxin like 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 276.2), Brain (RPKM 224.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Txnl4a in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (75934085..75949873)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73659107..73674893)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76725221..76740673)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene 60S acidic ribosomal protein P0 pseudogene Neighboring gene ribosome binding factor A Neighboring gene N(alpha)-acetyltransferase 12, NatA catalytic subunit Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene solute carrier family 66 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of causative variants in TXNL4A in Burn-McKeown syndrome and isolated choanal atresia. Goos JAC, et al. Eur J Hum Genet, 2017 Oct. PMID 28905882, Free PMC Article
    2. Compound heterozygosity of low-frequency promoter deletions and rare loss-of-function mutations in TXNL4A causes Burn-McKeown syndrome. Wieczorek D, et al. Am J Hum Genet, 2014 Dec 4. PMID 25434003, Free PMC Article
    3. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article
    4. Molecular architecture of the human U4/U6.U5 tri-snRNP. Agafonov DE, et al. Science, 2016 Mar 25. PMID 26912367
    5. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Bertram K, et al. Cell, 2017 Aug 10. PMID 28781166

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin-like protein 4A
    Names
    thioredoxin-like protein 4A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309168.1 → NP_001296097.1  thioredoxin-like protein 4A

      Status: VALIDATED

      Source sequence(s)
      FM059279, JAXUCZ010000018
      UniProtKB/TrEMBL
      A6K5G5, D3ZSW5
      Related
      ENSRNOP00000073923.1, ENSRNOT00000089487.3
      Conserved Domains (1) summary
      PLN00410
      Location:1 → 142
      PLN00410; U5 snRNP protein, DIM1 family; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      75934085..75949873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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