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    Ndst2 N-deacetylase and N-sulfotransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114002, updated on 9-Dec-2024

    Summary

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    Symbol
    Ndst2provided by RGD
    Full Name
    N-deacetylase and N-sulfotransferase 2provided by RGD
    Primary source
    RGD:1304700
    See related
    EnsemblRapid:ENSRNOG00000057755 AllianceGenome:RGD:1304700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylglucosamine deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity; and heparan sulfate N-deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to act upstream of or within heparan sulfate proteoglycan biosynthetic process; mast cell mediated immunity; and regulation of angiotensin levels in blood. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 71.3), Lung (RPKM 59.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndst2 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3612775..3623061)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3563515..3573801)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (3995797..4006491)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352872 Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene zinc finger, SWIM-type containing 8 Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Forsberg E, et al. Nature, 1999 Aug 19. PMID 10466727
    2. Heparin is essential for the storage of specific granule proteases in mast cells. Humphries DE, et al. Nature, 1999 Aug 19. PMID 10466726
    3. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. Lundequist A, et al. J Biol Chem, 2004 Jul 30. PMID 15173164
    4. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. Aikawa J, et al. J Biol Chem, 2001 Feb 23. PMID 11087757
    5. The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. McCormick C, et al. Proc Natl Acad Sci U S A, 2000 Jan 18. PMID 10639137, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparan sulfate N-deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mast cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of angiotensin levels in blood ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
    Names
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
    N-deacetylase/N-sulfotransferase 2
    NP_001099210.1
    XP_008768699.1
    XP_008768701.1
    XP_038948874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105740.2 → NP_001099210.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

      See identical proteins and their annotated locations for NP_001099210.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKQ3, A6KKQ5, D3ZD62
      Related
      ENSRNOP00000073946.1, ENSRNOT00000078653.3
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:26 → 514
      HSNSD; heparan sulfate-N-deacetylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      3612775..3623061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092946.1 → XP_038948874.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A6KKQ3, A6KKQ5, D3ZD62
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:26 → 514
      HSNSD; heparan sulfate-N-deacetylase

    2. XM_008770477.4 → XP_008768699.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2

      See identical proteins and their annotated locations for XP_008768699.1

      UniProtKB/TrEMBL
      A6KKQ3
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 796
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:26 → 514
      HSNSD; heparan sulfate-N-deacetylase

    3. XM_008770479.4 → XP_008768701.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X3

      See identical proteins and their annotated locations for XP_008768701.1

      UniProtKB/TrEMBL
      A6KKQ3
      Conserved Domains (2) summary
      pfam12062
      Location:26 → 514
      HSNSD; heparan sulfate-N-deacetylase
      cl21551
      Location:603 → 714
      Sulfotransfer_1; Sulfotransferase domain

    RNA

    1. XR_005493682.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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