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    Atp6ap2 ATPase H+ transporting accessory protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302526, updated on 4-Jan-2025

    Summary

    Official Symbol
    Atp6ap2provided by RGD
    Official Full Name
    ATPase H+ transporting accessory protein 2provided by RGD
    Primary source
    RGD:1561269
    See related
    EnsemblRapid:ENSRNOG00000003858 AllianceGenome:RGD:1561269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including angiotensin maturation; nervous system development; and regulation of signal transduction. Located in apical plasma membrane; cell body; and extracellular space. Is active in synaptic vesicle membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ATP6AP2 (ATPase H+ transporting accessory protein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 815.9), Kidney (RPKM 731.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atp6ap2 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (12856708..12883670, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (10183983..10210948, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (11137889..11164854, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 14 Neighboring gene similar to human chromosome X open reading frame 38 Neighboring gene mitochondrial pyruvate carrier 1-like Neighboring gene uncharacterized LOC120099278 Neighboring gene uncharacterized LOC102549122

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC94783

    Gene Ontology Provided by RGD

    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in angiotensin maturation  
    involved_in angiotensin maturation  
    involved_in biological_process  
    involved_in central nervous system maturation  
    involved_in central nervous system maturation  
    involved_in central nervous system maturation  
    involved_in eye pigmentation  
    involved_in eye pigmentation  
    involved_in head morphogenesis  
    involved_in head morphogenesis  
    involved_in lysosomal lumen acidification  
    involved_in lysosomal lumen acidification  
    involved_in lysosomal lumen acidification  
    involved_in positive regulation of Wnt signaling pathway  
    involved_in positive regulation of Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of transforming growth factor beta1 production  
    involved_in positive regulation of transforming growth factor beta1 production  
    involved_in regulation of MAPK cascade  
    involved_in regulation of MAPK cascade  
    involved_in rostrocaudal neural tube patterning  
    involved_in rostrocaudal neural tube patterning  
    involved_in synaptic vesicle lumen acidification  
    involved_in synaptic vesicle lumen acidification  
    Items 1 - 25 of 26
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in autophagosome membrane  
    located_in axon  
    located_in cell body PubMed 
    located_in clathrin-coated vesicle membrane  
    located_in dendritic spine membrane  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in endosome membrane  
    located_in endosome membrane  
    located_in endosome membrane  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in extracellular space PubMed 
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosome  
    located_in membrane  
    located_in postsynaptic membrane  
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  
    part_of vacuolar proton-transporting V-type ATPase complex  
    part_of vacuolar proton-transporting V-type ATPase complex  
    part_of vacuolar proton-transporting V-type ATPase complex  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    renin receptor
    Names
    ATPase, H(+)-transporting, lysosomal-interacting protein 2
    ATPase, H+ transporting, lysosomal accessory protein 2
    renin/prorenin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007091.1NP_001007092.1  renin receptor precursor

      See identical proteins and their annotated locations for NP_001007092.1

      Status: PROVISIONAL

      Source sequence(s)
      AB188298
      UniProtKB/Swiss-Prot
      Q6AXS4
      UniProtKB/TrEMBL
      A0A8L2UHU2, A6K003
      Related
      ENSRNOP00000110248.1, ENSRNOT00000153135.1
      Conserved Domains (1) summary
      pfam07850
      Location:255350
      Renin_r; Renin receptor-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      12856708..12883670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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