Tmem132a transmembrane protein 132A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem132aprovided by RGD
Official Full Name: transmembrane protein 132Aprovided by RGD
Primary source: RGD:727936
See related: EnsemblRapid:ENSRNOG00000021338 AllianceGenome:RGD:727936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gbp; Hspa5bp1
Summary: Predicted to enable protein homodimerization activity. Involved in cellular response to hydrogen peroxide and negative regulation of programmed cell death. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM132A (transmembrane protein 132A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 379.8), Lung (RPKM 173.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216931962..216943644, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207507074..207518756, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226912562..226925023, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRP78 in astroglia could strongly chelate with Pb ions.
Title: Chelation of GRP78 with lead and its localization changes in the astroglia of rats exposed to lead.
GRP78 is involved in IL-6 secretion from astrocytes, and lead can block IL-6 secretion from astrocytes via targeting GRP78
Title: A 78-kDa glucose-regulated protein is involved in the decrease of interleukin-6 secretion by lead treatment from astrocytes.
cloning and characterization of GRP78-binding protein that plays a role in embryonic and postnatal development of the brain
Title: Cloning and characterization of a novel GRP78-binding protein in the rat brain.
Mitochondrial calcium-mediated reactive oxygen species are essential for the rapid transactivation of the grp78 gene.
Title: Mitochondrial calcium-mediated reactive oxygen species are essential for the rapid induction of the grp78 gene in 9L rat brain tumour cells.
ER stress proteins (GRP78 and ORP150), respectively) were upregulated at PTCs in experimental proteinuric rats.
Title: Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.
These results suggest a novel function of GBP in regulating GFAP gene expression via STAT3 phosphorylation.
Title: GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells.

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General gene information

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Markers

RH125077 (e-PCR)
- UniSTS:161899

AI178537 (e-PCR)
- UniSTS:261058

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Wnt protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 132A

Names: GRP78-binding protein; HSPA5-binding protein 1; heat shock 70kDa protein 5 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415950.1 → NP_001402879.1 transmembrane protein 132A isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q80WF4

Related

ENSRNOP00000037012.4, ENSRNOT00000028971.6
NM_178021.2 → NP_821140.2 transmembrane protein 132A isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q80WF4

UniProtKB/TrEMBL

A6I062, G3V963