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    Opa1 OPA1, mitochondrial dynamin like GTPase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171116, updated on 4-Jan-2025

    Summary

    Official Symbol
    Opa1provided by RGD
    Official Full Name
    OPA1, mitochondrial dynamin like GTPaseprovided by RGD
    Primary source
    RGD:708423
    See related
    EnsemblRapid:ENSRNOG00000001717 AllianceGenome:RGD:708423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables kinase binding activity. Involved in several processes, including cellular response to L-glutamate; intracellular distribution of mitochondria; and positive regulation of cellular component organization. Located in mitochondrial inner membrane. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; ocular hypertension; rhinitis; and steatotic liver disease. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 466.4), Brain (RPKM 319.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Opa1 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (84612943..84690025, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (71108100..71185170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (74717600..74793902, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481018 Neighboring gene uncharacterized LOC134481019 Neighboring gene ATPase 13A4 Neighboring gene interleukin 13 receptor subunit alpha 1, pseudogene 1 Neighboring gene uncharacterized LOC102552083

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC124921

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase-dependent fusogenic activity  
    enables GTPase-dependent fusogenic activity  
    enables GTPase-dependent fusogenic activity  
    enables cardiolipin binding  
    enables cardiolipin binding  
    enables cardiolipin binding  
    enables kinase binding PubMed 
    enables lipid binding  
    enables membrane bending activity  
    enables membrane bending activity  
    enables membrane bending activity  
    enables membrane scission GTPase motor activity  
    enables metal ion binding  
    enables microtubule binding  
    enables phosphatidic acid binding  
    enables phosphatidic acid binding  
    enables phosphatidic acid binding  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 69
    Process Evidence Code Pubs
    involved_in GTP metabolic process  
    involved_in GTP metabolic process  
    involved_in GTP metabolic process  
    involved_in apoptotic process  
    involved_in calcium import into the mitochondrion PubMed 
    involved_in cellular response to L-glutamate PubMed 
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular senescence  
    involved_in cellular senescence  
    involved_in cellular senescence  
    involved_in cochlea development PubMed 
    involved_in cristae formation  
    involved_in cristae formation  
    involved_in endocytosis  
    involved_in inner mitochondrial membrane organization  
    involved_in inner mitochondrial membrane organization  
    involved_in intracellular distribution of mitochondria  
    involved_in intracellular distribution of mitochondria PubMed 
    involved_in membrane fusion  
    involved_in membrane tubulation  
    involved_in membrane tubulation  
    involved_in membrane tubulation  
    involved_in mitochondrial fission  
    involved_in mitochondrial fusion  
    involved_in mitochondrial fusion  
    involved_in mitochondrial fusion  
    involved_in mitochondrial genome maintenance  
    involved_in mitochondrial genome maintenance  
    involved_in mitochondrial genome maintenance  
    involved_in mitochondrial inner membrane fusion  
    involved_in mitochondrial inner membrane fusion  
    involved_in mitochondrial inner membrane fusion  
    involved_in mitochondrion organization PubMed 
    involved_in mitochondrion organization PubMed 
    acts_upstream_of_or_within mitochondrion organization  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in neural tube closure  
    acts_upstream_of_or_within neural tube closure  
    involved_in peroxisome fission  
    involved_in positive regulation of T-helper 17 cell lineage commitment  
    involved_in positive regulation of T-helper 17 cell lineage commitment  
    involved_in positive regulation of T-helper 17 cell lineage commitment  
    involved_in positive regulation of cellular response to insulin stimulus PubMed 
    involved_in positive regulation of dendrite development PubMed 
    involved_in positive regulation of dendritic spine morphogenesis PubMed 
    involved_in positive regulation of insulin receptor signaling pathway PubMed 
    involved_in positive regulation of interleukin-17 production  
    involved_in positive regulation of interleukin-17 production  
    involved_in positive regulation of interleukin-17 production  
    involved_in positive regulation of mitochondrial fusion PubMed 
    involved_in positive regulation of neuron maturation PubMed 
    involved_in protein complex oligomerization  
    involved_in protein complex oligomerization  
    involved_in response to curcumin PubMed 
    involved_in response to electrical stimulus PubMed 
    involved_in response to muscle activity PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in retina development in camera-type eye PubMed 
    involved_in visual perception  
    involved_in visual perception  
    involved_in visual perception  
    Items 1 - 25 of 69
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    located_in dendrite  
    located_in dendrite  
    is_active_in microtubule  
    located_in mitochondrial crista  
    located_in mitochondrial crista  
    located_in mitochondrial crista  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    is_active_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    is_active_in mitochondrial membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    dynamin-like GTPase OPA1, mitochondrial; dynamin-like 120 kDa protein, mitochondrial
    Names
    RN protein
    mitochondrial OPA1
    optic atrophy 1 (autosomal dominant)
    optic atrophy 1 homolog
    optic atrophy 1-like protein
    optic atrophy protein 1 homolog
    NP_598269.3
    XP_006248559.1
    XP_006248560.1
    XP_006248561.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433907.1NP_001420836.1  dynamin-like GTPase OPA1, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6A517, A0A8L2PZL8
    2. NM_001433908.1NP_001420837.1  dynamin-like GTPase OPA1, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8L2PZL8
    3. NM_001433909.1NP_001420838.1  dynamin-like GTPase OPA1, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8L2PZL8, A0A8L2Q0I8
    4. NM_001433910.1NP_001420839.1  dynamin-like GTPase OPA1, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I5ZZK0, A0A8L2PZL8
    5. NM_001433911.1NP_001420840.1  dynamin-like GTPase OPA1, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8L2PZL8
    6. NM_133585.4NP_598269.3  dynamin-like GTPase OPA1, mitochondrial isoform 4 precursor

      See identical proteins and their annotated locations for NP_598269.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      O08681, Q2TA68, Q5MPP1, Q5MPP2, Q5QJE9, Q6B435, Q6R611
      UniProtKB/TrEMBL
      A0A8L2PZL8
      Related
      ENSRNOP00000084440.1, ENSRNOT00000117359.2
      Conserved Domains (1) summary
      cd08771
      Location:287561
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      84612943..84690025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248498.3XP_006248560.1  dynamin-like 120 kDa protein, mitochondrial isoform X2

      Related
      ENSRNOP00000079139.1, ENSRNOT00000111984.2
      Conserved Domains (1) summary
      cd08771
      Location:324598
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    2. XM_006248497.3XP_006248559.1  dynamin-like 120 kDa protein, mitochondrial isoform X1

      Related
      ENSRNOP00000086026.1, ENSRNOT00000104752.2
      Conserved Domains (1) summary
      cd08771
      Location:342616
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    3. XM_006248499.3XP_006248561.1  dynamin-like 120 kDa protein, mitochondrial isoform X3

      Related
      ENSRNOP00000002343.7, ENSRNOT00000002343.9
      Conserved Domains (1) summary
      cd08771
      Location:305579
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
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