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    Txnl1 thioredoxin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Txnl1provided by RGD
    Official Full Name
    thioredoxin-like 1provided by RGD
    Primary source
    RGD:621717
    See related
    EnsemblRapid:ENSRNOG00000018818 AllianceGenome:RGD:621717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Txnl
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be located in cytoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 265.9), Muscle (RPKM 223.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Txnl1 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (59397275..59428072, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57125362..57155167, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59056454..59086278, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon GGC) 5 Neighboring gene uncharacterized LOC134482983 Neighboring gene WD repeat domain 7 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108348800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The redox sensor TXNL1 plays a regulatory role in fluid phase endocytosis. Felberbaum-Corti M, et al. PLoS One, 2007 Nov 7. PMID 17987124, Free PMC Article
    2. Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa. Lee KK, et al. J Biol Chem, 1998 Jul 24. PMID 9668102
    3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114276

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin-like protein 1
    Names
    thioredoxin-like (32kD)
    thioredoxin-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080887.2 → NP_543163.1  thioredoxin-like protein 1

      See identical proteins and their annotated locations for NP_543163.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098908
      UniProtKB/Swiss-Prot
      Q920J4
      UniProtKB/TrEMBL
      A0A8I5ZZI7, A6IXM8
      Related
      ENSRNOP00000025510.2, ENSRNOT00000025510.6
      Conserved Domains (2) summary
      cd02947
      Location:12 → 104
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:128 → 268
      PITH; PITH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      59397275..59428072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254827.5 → XP_006254889.1  thioredoxin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K737, A0A8I5ZZI7
      Conserved Domains (2) summary
      cd02947
      Location:12 → 104
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:126 → 268
      PITH; PITH domain

    2. XM_063277080.1 → XP_063133150.1  thioredoxin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWH0, A0A8I5ZZI7
      Related
      ENSRNOP00000084077.1, ENSRNOT00000093914.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920J4.3 GenPept UniProtKB/Swiss-Prot:Q920J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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