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    Ripor1 RHO family interacting cell polarization regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291974, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ripor1provided by RGD
    Official Full Name
    RHO family interacting cell polarization regulator 1provided by RGD
    Primary source
    RGD:1307772
    See related
    EnsemblRapid:ENSRNOG00000017604 AllianceGenome:RGD:1307772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam65a; RGD1307772
    Summary
    Predicted to enable 14-3-3 protein binding activity. Predicted to be involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Predicted to be located in Golgi apparatus; cell leading edge; and membrane. Predicted to be active in cytoplasm. Orthologous to human RIPOR1 (RHO family interacting cell polarization regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 148.7), Lung (RPKM 86.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ripor1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50387447..50416323)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33477750..33506424)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37555940..37584842)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit D1 Neighboring gene uncharacterized LOC134483348 Neighboring gene small nuclear ribonucleoprotein E-like Neighboring gene agouti related neuropeptide Neighboring gene CCCTC-binding factor like 2 Neighboring gene CCCTC-binding factor Neighboring gene capping protein regulator and myosin 1 linker 2 Neighboring gene ACD, shelterin complex subunit and telomerase recruitment factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding  
    enables 14-3-3 protein binding  
    enables 14-3-3 protein binding  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    involved_in cellular response to chemokine  
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    involved_in establishment of Golgi localization  
    involved_in establishment of Golgi localization  
    involved_in establishment of Golgi localization  
    involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity  
    involved_in negative regulation of Rho protein signal transduction  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of intracellular protein transport  
    involved_in protein localization to Golgi apparatus  
    involved_in protein localization to Golgi apparatus  
    involved_in protein localization to Golgi apparatus  
    involved_in response to wounding  
    involved_in response to wounding  
    involved_in response to wounding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in cell leading edge  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in membrane  
    located_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    rho family-interacting cell polarization regulator 1
    Names
    family with sequence similarity 65, member A
    protein FAM65A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100660.1NP_001094130.1  rho family-interacting cell polarization regulator 1

      See identical proteins and their annotated locations for NP_001094130.1

      Status: VALIDATED

      Source sequence(s)
      AY724537, BF524907, FQ147070
      UniProtKB/Swiss-Prot
      Q4FZU8
      UniProtKB/TrEMBL
      A0A0G2JVR9, A6IYQ8
      Related
      ENSRNOP00000096363.2, ENSRNOT00000116738.2
      Conserved Domains (4) summary
      pfam05109
      Location:497747
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:10911121
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:11191183
      HEAT_2; HEAT repeats
      pfam15903
      Location:17365
      PL48; Filopodia upregulated, FAM65

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50387447..50416323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277922.1XP_063133992.1  rho family-interacting cell polarization regulator 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JVR9, A6IYQ6
      Related
      ENSRNOP00000023710.6, ENSRNOT00000023710.8
    2. XM_063277924.1XP_063133994.1  rho family-interacting cell polarization regulator 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JVR9
      Related
      ENSRNOP00000102696.1, ENSRNOT00000139880.1
    3. XM_063277921.1XP_063133991.1  rho family-interacting cell polarization regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JVR9
    4. XM_063277923.1XP_063133993.1  rho family-interacting cell polarization regulator 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JVR9
    5. XM_006255474.5XP_006255536.1  rho family-interacting cell polarization regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVR9, A0A8I6B430
      Related
      ENSRNOP00000069592.3, ENSRNOT00000089022.3
      Conserved Domains (3) summary
      pfam13646
      Location:11341197
      HEAT_2; HEAT repeats
      pfam15903
      Location:31379
      PL48; Filopodia upregulated, FAM65
      sd00044
      Location:11051135
      HEAT; HEAT repeat [structural motif]
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