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    Lamb2 laminin subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25473, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lamb2provided by RGD
    Official Full Name
    laminin subunit beta 2provided by RGD
    Primary source
    RGD:2988
    See related
    EnsemblRapid:ENSRNOG00000047768 AllianceGenome:RGD:2988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SLAM
    Summary
    Predicted to enable integrin binding activity. Predicted to be a structural constituent of synapse-associated extracellular matrix. Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including metanephric glomerulus development; neurogenesis; and visual perception. Predicted to be located in basement membrane and synapse. Predicted to be part of laminin-3 complex. Predicted to be active in neuromuscular junction and synaptic cleft. Used to study proteinuria. Human ortholog(s) of this gene implicated in Pierson syndrome; nephrotic syndrome type 5; and primary open angle glaucoma. Orthologous to human LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 741.8), Uterus (RPKM 372.8) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lamb2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118056899..118069090)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109178367..109190552)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117268335..117280517)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 8B Neighboring gene coiled-coil domain containing 71 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene glutaminyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93588

    Gene Ontology Provided by RGD

    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in Schwann cell development  
    acts_upstream_of_or_within Schwann cell development  
    involved_in animal organ morphogenesis  
    involved_in astrocyte development  
    acts_upstream_of_or_within astrocyte development  
    involved_in axon extension involved in regeneration  
    acts_upstream_of_or_within axon extension involved in regeneration  
    involved_in axon guidance  
    involved_in axon guidance  
    acts_upstream_of_or_within axon guidance  
    involved_in basement membrane assembly  
    involved_in cell adhesion  
    involved_in cell migration  
    acts_upstream_of_or_within cell morphogenesis  
    involved_in metanephric glomerular basement membrane development  
    acts_upstream_of_or_within metanephric glomerular basement membrane development  
    involved_in metanephric podocyte development  
    acts_upstream_of_or_within metanephric podocyte development  
    involved_in neuromuscular junction development  
    acts_upstream_of_or_within neuromuscular junction development  
    acts_upstream_of_or_within neuron projection development  
    involved_in retina development in camera-type eye  
    acts_upstream_of_or_within retina development in camera-type eye  
    involved_in substrate adhesion-dependent cell spreading  
    acts_upstream_of_or_within synapse organization  
    involved_in tissue development  
    involved_in visual perception  
    acts_upstream_of_or_within visual perception  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in basement membrane  
    located_in basement membrane  
    located_in extracellular region  
    part_of laminin complex  
    part_of laminin complex  
    part_of laminin-3 complex  
    part_of laminin-3 complex  
    located_in neuromuscular junction  
    is_active_in neuromuscular junction  
    located_in synapse  
    located_in synaptic cleft  
    is_active_in synaptic cleft  

    General protein information

    Preferred Names
    laminin subunit beta-2
    Names
    S-LAM beta
    S-laminin subunit beta
    laminin chain B3
    laminin chain beta 2
    laminin, beta 2
    laminin-11 subunit beta
    laminin-14 subunit beta
    laminin-15 subunit beta
    laminin-3 subunit beta
    laminin-4 subunit beta
    laminin-7 subunit beta
    laminin-9 subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012974.1NP_037106.1  laminin subunit beta-2 precursor

      See identical proteins and their annotated locations for NP_037106.1

      Status: VALIDATED

      Source sequence(s)
      X16563
      UniProtKB/Swiss-Prot
      P15800
      UniProtKB/TrEMBL
      Q5M7W9
      Conserved Domains (9) summary
      TIGR02473
      Location:14771617
      flagell_FliJ; flagellar export protein FliJ
      smart00180
      Location:786831
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:524565
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:11461185
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60284
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam12795
      Location:15821776
      MscS_porin; Mechanosensitive ion channel porin domain
      pfam14346
      Location:14461516
      DUF4398; Domain of unknown function (DUF4398)
      cl15454
      Location:14851673
      HrpJ; HrpJ-like domain
      cl21478
      Location:16841795
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118056899..118069090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243709.4XP_006243771.1  laminin subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006243771.1

      UniProtKB/TrEMBL
      A6I359, M0R6K0, Q5M7W9
      Related
      ENSRNOP00000065052.1, ENSRNOT00000072098.4
      Conserved Domains (9) summary
      TIGR02473
      Location:14771617
      flagell_FliJ; flagellar export protein FliJ
      smart00180
      Location:786831
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:524565
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:11461185
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60284
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam12795
      Location:15821776
      MscS_porin; Mechanosensitive ion channel porin domain
      pfam14346
      Location:14461516
      DUF4398; Domain of unknown function (DUF4398)
      cl15454
      Location:14851673
      HrpJ; HrpJ-like domain
      cl21478
      Location:16841795
      ATP-synt_B; ATP synthase B/B' CF(0)
    2. XM_039080881.1XP_038936809.1  laminin subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      Q5M7W9
      Conserved Domains (6) summary
      smart00180
      Location:786831
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG1196
      Location:12051798
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00055
      Location:524565
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:11461193
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:51284
      Laminin_N; Laminin N-terminal (Domain VI)
      cd22299
      Location:17291800
      cc_LAMB2_C; C-terminal coiled-coil domain found in laminin subunit beta-2 (LAMB2)
    3. XM_039080882.2XP_038936810.1  laminin subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      Q5M7W9
      Conserved Domains (6) summary
      smart00180
      Location:652697
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG1196
      Location:10711665
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00055
      Location:390431
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:10121059
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:2150
      Laminin_N; Laminin N-terminal (Domain VI)
      cd22299
      Location:15961667
      cc_LAMB2_C; C-terminal coiled-coil domain found in laminin subunit beta-2 (LAMB2)
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