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    Rabep1 rabaptin, RAB GTPase binding effector protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54190, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rabep1provided by RGD
    Official Full Name
    rabaptin, RAB GTPase binding effector protein 1provided by RGD
    Primary source
    RGD:708568
    See related
    EnsemblRapid:ENSRNOG00000005015 AllianceGenome:RGD:708568
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein domain specific binding activity and protein homodimerization activity. Predicted to be involved in Golgi to plasma membrane transport; protein localization to ciliary membrane; and regulation of postsynaptic neurotransmitter receptor internalization. Is active in presynaptic cytosol. Orthologous to human RABEP1 (rabaptin, RAB GTPase binding effector protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 248.6), Liver (RPKM 125.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rabep1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (56064742..56168778)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55566156..55667595)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57462272..57579901)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SLP adaptor and CSK interacting membrane protein Neighboring gene uncharacterized LOC120095133 Neighboring gene transfer RNA serine (anticodon AGA) 18 Neighboring gene nucleoporin 88 Neighboring gene RPA interacting protein Neighboring gene complement C1q binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables growth factor activity  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport  
    involved_in Golgi to plasma membrane transport  
    involved_in Golgi to plasma membrane transport  
    involved_in Golgi to plasma membrane transport  
    involved_in apoptotic process  
    involved_in endocytosis  
    involved_in protein localization to ciliary membrane  
    involved_in protein localization to ciliary membrane  
    involved_in protein localization to ciliary membrane  
    involved_in protein transport  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    involved_in signal transduction  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    located_in early endosome  
    is_active_in endocytic vesicle  
    located_in endocytic vesicle  
    located_in endocytic vesicle  
    located_in endocytic vesicle  
    is_active_in endosome  
    located_in endosome  
    located_in endosome  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    is_active_in presynaptic cytosol PubMed 
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in recycling endosome  

    General protein information

    Preferred Names
    rab GTPase-binding effector protein 1
    Names
    rabaptin-5
    rabaptin-5alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019124.2NP_061997.2  rab GTPase-binding effector protein 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O35550, P70609
      UniProtKB/TrEMBL
      A6HGA2
      Related
      ENSRNOP00000090309.2, ENSRNOT00000109255.2
      Conserved Domains (2) summary
      pfam03528
      Location:9495
      Rabaptin
      pfam09311
      Location:533839
      Rab5-bind; Rabaptin-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      56064742..56168778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269681.1XP_063125751.1  rab GTPase-binding effector protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35550, P70609
      Related
      ENSRNOP00000104261.1, ENSRNOT00000128672.1
    2. XM_006246795.5XP_006246857.1  rab GTPase-binding effector protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O35550, P70609
      Related
      ENSRNOP00000093398.2, ENSRNOT00000107871.2
      Conserved Domains (3) summary
      pfam03528
      Location:9495
      Rabaptin; Rabaptin
      pfam09311
      Location:518804
      Rab5-bind; Rabaptin-like protein
      pfam10267
      Location:613749
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    3. XM_063269682.1XP_063125752.1  rab GTPase-binding effector protein 1 isoform X3

      UniProtKB/Swiss-Prot
      O35550, P70609
    4. XM_006246796.5XP_006246858.1  rab GTPase-binding effector protein 1 isoform X4

      UniProtKB/Swiss-Prot
      O35550, P70609
      Related
      ENSRNOP00000100373.1, ENSRNOT00000137271.1
      Conserved Domains (2) summary
      pfam03528
      Location:9495
      Rabaptin; Rabaptin
      pfam10267
      Location:574710
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    5. XM_008767861.4XP_008766083.1  rab GTPase-binding effector protein 1 isoform X5

      See identical proteins and their annotated locations for XP_008766083.1

      UniProtKB/TrEMBL
      A0A8I5ZKK4, A6HGA4, A6HGA5
      Conserved Domains (3) summary
      pfam03528
      Location:1411
      Rabaptin; Rabaptin
      pfam09311
      Location:449755
      Rab5-bind; Rabaptin-like protein
      pfam10267
      Location:564700
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RNA

    1. XR_594720.4 RNA Sequence

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