Galp galanin-like peptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Galpprovided by RGD
Official Full Name: galanin-like peptideprovided by RGD
Primary source: RGD:620187
See related: EnsemblRapid:ENSRNOG00000022129 AllianceGenome:RGD:620187
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hormone activity. Involved in response to insulin. Predicted to be located in extracellular region. Biomarker of obesity. Orthologous to human GALP (galanin like peptide). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (76717110..76741056, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (67684023..67703121, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (71352417..71374457, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats.
Title: Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats.
These data suggest that GALP activates feeding and sexual behaviors in male rats by stimulating dopaminergic neurons that terminate within the mPOA.
Title: Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats.
GALP-containing neurons innervate tuberoinfundibular dopaminergic neurons
Title: Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus.
regulatory mechanism of GALP mRNA is different from that of the neuropeptide Y and proopiomelanocortin genes during postnatal development
Title: Postnatal development of galanin-like peptide mRNA expression in rat hypothalamus.
GALP gene expression in rats might be regulated by leptin-independent mechanisms.
Title: Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat.
hypothalamic GALP gene expression is controlled by leptin signals and suggests possible involvement of GALP in the reproductive abnormalities of the Zucker obese rat.
Title: Changes in hypothalamic expression levels of galanin-like peptide in rat and mouse models support that it is a leptin-target peptide.
This is the first study to demonstrate close apposition of galanin-like peptide (GALP)-immunoreactive cell bodies and GALP neurons expressing OX1-receptors in direct contact with orexin (OX1)-immunoreactive terminals in the arcuate nucleus.
Title: Galanin-like peptide is target for regulation by orexin in the rat hypothalamus.
observations demonstrate that endogenous Galanin-like peptide (GALP)provides trophic support to the neuroendocrine reproductive axis, including sexual behavior
Title: Galanin-like peptide rescues reproductive function in the diabetic rat.
findings suggest that galanin-like peptide may mediate the actions of leptin on the reproductive axis
Title: Galanin-like peptide stimulates the release of gonadotropin-releasing hormone in vitro and may mediate the effects of leptin on the hypothalamo-pituitary-gonadal axis.
adaptive responses in GALP signaling might occur during chronic overfeeding
Title: Exaggerated feeding response to central galanin-like peptide administration in diet-induced obese rats.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within behavioral response to starvation	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galanin-like peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022633.3 → NP_072155.1 galanin-like peptide precursor

See identical proteins and their annotated locations for NP_072155.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9QXQ6

Related

ENSRNOP00000038710.2, ENSRNOT00000034854.4

Conserved Domains (1) summary

smart00071
Location:24 → 44

Galanin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

76717110..76741056 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272782.1 → XP_063128852.1 galanin-like peptide isoform X2

UniProtKB/TrEMBL

A6KS77
XM_063272781.1 → XP_063128851.1 galanin-like peptide isoform X1