Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpihbp1provided by RGD
Official Full Name: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1provided by RGD
Primary source: RGD:1564237
See related: EnsemblRapid:ENSRNOG00000064680 AllianceGenome:RGD:1564237
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564237
Summary: Predicted to enable several functions, including lipase binding activity; lipoprotein lipase activator activity; and lipoprotein particle binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; positive regulation of chylomicron remnant clearance; and protein transport. Predicted to act upstream of or within lipid transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and external side of plasma membrane. Predicted to be part of catalytic complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in familial GPIHBP1 deficiency. Orthologous to human GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 84.8), Lung (RPKM 77.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109166334..109169448)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107285584..107288702)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (116632496..116635543)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats.
Title: AAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats.
Cardiomyocyte VEGF activates EC Notch signaling, facilitating GPIHBP1-mediated translocation of LPL across EC and regulating LPL-derived fatty acid delivery to the cardiomyocytes.
Title: Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chylomicron binding	IBA Inferred from Biological aspect of Ancestor more info
enables chylomicron binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables lipase binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipase binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activator activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables protein transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in protein import	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in response to heparin	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Names: GPI-anchored HDL-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130547.1 → NP_001124019.1 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 precursor

See identical proteins and their annotated locations for NP_001124019.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A6HS12, D3ZZL5

Related

ENSRNOP00000093917.1, ENSRNOT00000103232.2

Conserved Domains (1) summary

cd00117
Location:69 → 146

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109166334..109169448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078806.2 → XP_038934734.1 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform X1

UniProtKB/TrEMBL

A6HS11

Conserved Domains (1) summary

cl10471
Location:69 → 102

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...