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    Plxna1 plexin A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362398, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plxna1provided by RGD
    Official Full Name
    plexin A1provided by RGD
    Primary source
    RGD:1560871
    See related
    EnsemblRapid:ENSRNOG00000017003 AllianceGenome:RGD:1560871
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560871
    Summary
    Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including nervous system development; positive regulation of axonogenesis; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection extension; and regulation of smooth muscle cell migration. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of semaphorin receptor complex. Predicted to be active in glutamatergic synapse and plasma membrane. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 197.4), Adrenal (RPKM 91.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Plxna1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (123295165..123340132, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121737934..121782901, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (121217658..121262697, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102339 Neighboring gene uncharacterized LOC120102340 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 6 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables semaphorin receptor activity  
    enables semaphorin receptor activity  
    Process Evidence Code Pubs
    involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  
    involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  
    acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching  
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus  
    acts_upstream_of_or_within neuron projection extension  
    involved_in neuron projection guidance  
    acts_upstream_of_or_within neuron projection guidance  
    involved_in olfactory nerve formation  
    involved_in regulation of cell migration  
    acts_upstream_of_or_within regulation of smooth muscle cell migration  
    involved_in semaphorin-plexin signaling pathway  
    involved_in semaphorin-plexin signaling pathway  
    involved_in synapse assembly  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse  
    located_in membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in plasma membrane  
    part_of semaphorin receptor complex  
    part_of semaphorin receptor complex  
    is_active_in synapse  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      123295165..123340132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002729398.6XP_002729444.2  plexin-A1

      See identical proteins and their annotated locations for XP_002729444.2

      UniProtKB/TrEMBL
      A0A8I6AGW9, A6IB60, D3Z981
      Related
      ENSRNOP00000099946.1, ENSRNOT00000137358.1
      Conserved Domains (7) summary
      cd11271
      Location:54529
      Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
      cd01179
      Location:9771062
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:880976
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10641164
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:530572
      PSI; Plexin repeat
      pfam01833
      Location:11661250
      TIG; IPT/TIG domain
      pfam08337
      Location:13341882
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
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