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    Bace2 beta-secretase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288227, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bace2provided by RGD
    Official Full Name
    beta-secretase 2provided by RGD
    Primary source
    RGD:1303241
    See related
    EnsemblRapid:ENSRNOG00000001953 AllianceGenome:RGD:1303241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 61.5), Lung (RPKM 44.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Bace2 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50176852..50258948)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (36707447..36789550)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (37798397..37880624)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule Neighboring gene uncharacterized LOC120095542 Neighboring gene uncharacterized LOC120095544 Neighboring gene MX dynamin like GTPase 1 Neighboring gene FAM3 metabolism regulating signaling molecule B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity  
    enables aspartic-type endopeptidase activity  
    enables peptidase activity  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in dense core granule PubMed 
    located_in endoplasmic reticulum  
    is_active_in endosome  
    located_in melanosome membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in trans-Golgi network  

    General protein information

    Preferred Names
    beta-secretase 2
    Names
    beta-site APP-cleaving enzyme 2
    beta-site amyloid precursor protein cleaving enzyme 2
    memapsin-1
    membrane-associated aspartic protease 1
    theta-secretase
    NP_001002802.1
    XP_038944130.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002802.2NP_001002802.1  beta-secretase 2 precursor

      See identical proteins and their annotated locations for NP_001002802.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      B2GVB0, Q6IE75
      UniProtKB/TrEMBL
      A6IQF8
      Related
      ENSRNOP00000002679.4, ENSRNOT00000002679.9
      Conserved Domains (2) summary
      cd05473
      Location:85446
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
      pfam00026
      Location:88425
      Asp; Eukaryotic aspartyl protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50176852..50258948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088202.2XP_038944130.1  beta-secretase 2 isoform X1

      Conserved Domains (1) summary
      cd05473
      Location:37382
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
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